Clusters of sleep-promoting neurons in many parts of the brain become more active as we get ready for bed.  Nerve-signaling chemicals called neurotransmitters can “switch off” or dampen the activity of cells that signal arousal or relaxation.  GABA is associated with sleep, muscle relaxation, and sedation.  Norepinephrine and orexin (also called hypocretin) keep some parts of the brain active while we are awake.  Other neurotransmitters that shape sleep and wakefulness include acetylcholine, histamine, adrenaline, cortisol, and serotonin.
We tend to think of sleep as a time when the mind and body shut down. But this is not the case; sleep is an active period in which a lot of important processing, restoration, and strengthening occurs. Exactly how this happens and why our bodies are programmed for such a long period of slumber is still somewhat of a mystery. But scientists do understand some of sleep's critical functions, and the reasons we need it for optimal health and wellbeing.
There are several different types of prescription sleeping pills, classified as sedative hypnotics. In general, these medications act by working on receptors in the brain to slow down the nervous system. Some medications are used more for inducing sleep, while others are used for staying asleep. Some last longer than others in your system (a longer half-life), and some have a higher risk of becoming habit forming.
Night shift workers often have trouble falling asleep when they go to bed, and also have trouble staying awake at work because their natural circadian rhythm and sleep-wake cycle is disrupted.  In the case of jet lag, circadian rhythms become out of sync with the time of day when people fly to a different time zone, creating a mismatch between their internal clock and the actual clock. 
Worry Earlier in the Day. When your mind is racing with concerns while you’re trying to fall asleep, that can make it nearly impossible to drift off. Instead, dedicate 15 minutes during the day to process these thoughts. Writing a to-do list or thinking about solutions can be a healthy way to deal with stress and prevent it from interfering with sleep later.
Night shift workers often have trouble falling asleep when they go to bed, and also have trouble staying awake at work because their natural circadian rhythm and sleep-wake cycle is disrupted.  In the case of jet lag, circadian rhythms become out of sync with the time of day when people fly to a different time zone, creating a mismatch between their internal clock and the actual clock. 
Français: mieux dormir, Italiano: Dormire Meglio, Español: dormir mejor, Deutsch: Besser schlafen, Português: Dormir Melhor, Nederlands: Beter slapen, 中文: 睡得更香, Русский: улучшить сон, Bahasa Indonesia: Tidur Lebih Nyenyak, Čeština: Jak mít lepší spánek, 日本語: よく眠る, العربية: أن تنعم بنوم أعمق وأهدأ, ไทย: นอนหลับให้สบาย, हिन्दी: बेहतर नींद लें, Tiếng Việt: Có Giấc ngủ Tốt hơn, 한국어: 더 잘 자는 법, Türkçe: Nasıl Rahat Uyunur
The key here is to keep dinners simple and moderate in portion, so you won’t be bothered with indigestion later. Eating carbs four hours before sleep was more effective than one hour prior in the study, meaning planning your evening meals could prove helpful. Spicy foods can also affect your ability to fall asleep quickly, so keep that in mind, too.
Use sleeping aids and devices: Experiment with white noise machines, adjustable beds, sleep masks, and indoor air purifiers if you need help sleeping. White noise machines or noise reducers create ambient or white noise, which makes it more difficult for a sleeper to hear any potentially disruptive noises. Adjustable beds can alleviate pain that can disturb sleep, especially for those suffering from hip and knee pain or acid reflux disease. A sleep mask tricks the brain into falling asleep more quickly for people who need to sleep or nap during daylight, and indoor air purifiers lessen symptoms suffered by those with allergies or nasal congestion.
Many herbal tonics support adrenal health and help balance energy levels, which allow us to work, exercise, and digest during the day, then drop into an alpha state during the night. My favorite herb for insomnia is ashwagandha, which helps to relax the body. Try 500–1,000 mg at bedtime for 6–12 months until you re-establish a healthy sleep pattern. Other effective bedtime herbs include valerian (especially if pain is part of your disturbed sleep quality), passionflower, lemon balm, and California poppy.
What I Did: Every night, I wrote down the time I ate dinner, when I turned off electronics, and what time I turned out the light. The next morning I added my wake up time and a brief note about how I slept. Even after only a week or two sleep journaling, I saw some interesting patterns (or lack of patterns) and knew what I needed to work on to get better sleep.
Falling asleep isn't always as simple as placing your head on a pillow and shutting your eyes. Thoughts and worries might race their way through your mind, or getting comfortable might seem impossible. Fortunately, from relaxation techniques to changing your sleep routine, there are lots of ways to fall asleep quickly and improve your sleep quality.
Sleep issues can often be traced back to an underlying issue. When we asked Dr. Breus for his first choice in treating sleep issues, he told us, “It’s never a pill. I would want to know the root cause. There could be an anxiety component where cognitive behavioral therapy could be helpful.” If you face sleeplessness regularly, it’s well worth speaking to your doctor about underlying causes.

Valerian (Valeriana officinalis) is a herbal home remedy, brewed as a tea or taken as a supplement, that is commonly used to reduce anxiety, improve sleep quality, and act as a sedative. Clinical trials of valerian have had inconsistent results for insomnia. Studies measuring sleep quality have found no difference between people taking valerian and those taking a placebo. However, a sizable number of people in the studies anecdotally reported that their sleep quality improved with valerian. 
A study published in Sports Medicine out of France was conducted to help better understand ways to improve the sleep of elite soccer players given their chaotic schedules, late-night games and need for recovery through a good night of sleep. The study found that by consuming carbohydrates — such as honey and whole grain bread — and some forms of protein, especially those that contain serotonin-producing tryptophan like turkey, nuts and seeds, it helped promote restorative sleep. Even tryptophan-filled tart cherry juice, which also contains healing properties like antioxidants, could be a great option. (3)
Trouble sleeping is often a symptom of another disease or condition, such as depression, chronic pain, medications, or stress, which might explain why it’s so common. Longitudinal course and impact of insomnia symptoms in adolescents with and without chronic pain. Palermo TM, Law E, Churchill SS. The journal of pain : official journal of the American Pain Society, 2012, Sep.;13(11):1528-8447.
Are you physically uncomfortable? A too soft or too firm mattress, an uncomfortable pillow, or an older, worn-out bed can all impede a good night’s sleep. Check your mattress for signs of wear at least twice a year, and consider new pillows. You may also want to see an osteopathic physician who specializes in osteopathic manipulative therapy. A session or two of this safe and effective sleep aid treatment can be life-changing.
Cherries. They’re the only edible source of the sleep hormone melatonin, so consider having a bowlful for dessert. If they’re not in season, opt for thawed frozen cherries or a glass of tart cherry juice. Drinking two glasses daily helped people with insomnia sleep for 90 more minutes, found one study published in the Journal of the Federation of American Societies for Experimental Biology.
Use a blue light filter on your device. The blue light emitted by smartphones and tablets can be a powerful sleep disruptor. It suppresses your body’s production of melatonin and throws your circadian rhythm off, making it harder to fall and stay asleep. Luckily, many smartphones these days have a “night shift” feature that adjusts the screen from cool (blue) to warm (yellow) light, which is less likely to keep you up past your bedtime. Likewise, there are apps you can run on your laptop or tablet that reduce blue light. Some popular ones are f.lux and Twilight.
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