This herb has been shown to prevent the activation of the transcriptional factor NF-kB and it directly inhibits TNF-α production by up to 65-85%. It inhibits the expression of inducible genes associated with inflammation, specifically negating the expression of inducible nitric oxide synthase, and hence attenuates nitrous oxide production. Side effects may include nausea, although it has shown an impressive protective effect on indomethacin-induced enteritis in laboratory studies.
"I am a true believer in Biofreeze ($15; performancehealth.com). My football coach introduced me to it years ago. It's a topical cooling pain reliever that works very similarly to ice but since it's a gel, I can apply it before teaching classes and training clients to keep function in my muscles and joints. In addition to relieving muscle pain or soreness, it can be used to help arthritis and other muscular and joint discomforts too. " —Mat Forzaglia, The Fhitting Room instructor
The omega-3 fatty acids found in abundance in fish oil derived from cod, trout, herring, salmon and other coldwater fish are proven natural remedies to reduce inflammation. Research from Cardiff University in Great Britain found that cod liver oil not only relieves pain, but also stops and even reverses the damage caused by osteoarthritis and rheumatoid arthritis. Omega-3s help morning stiffness, regenerate joint tissue and have been shown to also aid in autoimmune disease like RA, lupus and psoriasis.
Enjoy essential oils. Essential oils have long been valued for their analgesic effects in many cultures. There are many ways to benefit from essential oils—some people inhale them (aromatherapy), others include several drops in their massage oil and enjoy as part of a therapeutic massage. Several oils in particular are thought to have an analgesic effect, including peppermint oil, rosemary, and lavender.
Research has shown that the omega-3 polyunsaturated fatty acids are some of the most effective natural anti-inflammatory agents available.[12,23–25,27,50,85] With the discovery that vascular inflammation is the underlying cause of coronary artery disease, fish and fish oil supplements are now recommended by the American Heart Association for the prevention of this disease.[12,23–25,27,50,85] Countries that have the highest fish consumption also have a lower incidence of neurodegenerative disease and depression.[12,23–25,27,50,85] The biological basis for the effectiveness of fish oil in treating arthritis has been well documented with many positive clinical studies, when compared to traditional pharmaceutical anti-inflammatory agents.[12,23–25,27,50,85]
I will admit I wasn't a believer. I have torn my knees all up and have had surgery. Surgery fixed the torn meniscus but the pain didn't stop. So I got on the pain pill routine. I hate taking the pills they make me feel fuzzy. A friend recommended Topricin to me. I got some and used it. Within days I noticed I needed less pills. It really does help the pain. I love it IT WORKS! I still have the pills in case it gets really bad but most of the time the pain can be managed by using the cream. I even keep a small tube in my purse just in case I need it. It also helps to show people what I am using. An added benefit is that it doesn't smell.
Although it’s been available in Europe for many years, it was only approved for use in the United States in 2007. Also, other topical treatments (salicylates and capsaicin) have shown little potential in the past. And Arnica montana creams (Traumeel, for example) are extremely popular, but it’s unlikely that even full-strength arnica is medically potent, let alone when it is diluted down to traces.3
"There are three that I swear by. I use Icy Hot Roll-On ($5; walmart.com) on my feet at the end of the day after I do my exercises to stretch my feet. It's also great for traveling because it doesn't get messy! I like Salonpas Spray ($8; walmart.com) because it can get hard-to-reach places on my back or shoulder blades. And since Tiger Balm ($5; walmart.com) is strong, I use that when my legs are sore and I sleep with it on. I wake up the next morning and feel great." —Nicole Winhoffer, founder NW Method
The arnica Montana plant—also known as the mountain daisy—has been used for centuries to provide natural pain relief. For people who prefer a homeopathic approach to pain, the Boiron Arnica Cream is a great addition to your medicine cabinet. The non-sticky cream can help relieve muscle pain, stiffness, swelling, and bruise discoloration. It’s also a good option for sensitive skin thanks to the natural ingredients. It can even be applied to the face and is safe to use on children.
Get enough restorative sleep. Getting enough sleep is critical to managing pain and promoting healing, so it's important to employ a variety of sleep aids to help you get a healthy amount of sleep. Regular exercise that physically exhausts the body helps promote deep sleep. Visualization, meditation, and other psychological techniques can also help you get to sleep and stay asleep.
Not as popular as many other essential oils, arnica oil belongs in every medicine cabinet. Considered generally safe for topical use, arnica oil used on the skin helps ease inflammatory pain associated with insect bites, bruises and even arthritis flare-ups. (5, 6) To treat bruises, applying arnica oil twice daily (as long as the skin is not broken) helps reduce bruising inflammation even better than low-concentration vitamin K formulations. (3)

Release your inner endorphins. Endorphins are the natural pain relievers produced by your body. They work by binding to the opioid receptors in your brain to block the perception of pain, similar to opioid pain medications, such as oxycodone or morphine. Spurring increased production of these natural hormones can substantially help reduce your pain, as well as produce profound feelings of pleasure and satisfaction.1
Stay well hydrated. It is common knowledge that drinking enough water throughout the day is good for you, but did you know it can also help reduce pain? For people with back conditions, staying well hydrated helps the intervertebral discs stay healthy. Drinking enough water also helps reduce stiffness, it helps your blood carry healing nutrients and oxygen throughout the structures of you body, and helps flush toxins out of your muscles and other soft tissues. It will help prevent constipation (a side affect of many pain medications).
Over-the-counter (OTC) pain relievers. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), might relieve acute back pain. Take these medications only as directed by your doctor. Overuse can cause serious side effects. If OTC pain relievers don't relieve your pain, your doctor might suggest prescription NSAIDs.
Studies have shown that pycnogenol is 50–100 times more potent than vitamin E in neutralizing free radicals and that it helps to recycle and prolong the activity of vitamins C and E. Studies have shown pycnogenol to be effective in reducing blood pressure and reducing the risk of venous thrombosis by its effect on vascular endothelium. The usual dosage is 100–200 mg daily. Few side effects from the use of pine bark extracts have been reported, the most frequent being mild gastrointestinal effects such as diarrhea and upset stomach. Pycnogenol should not be taken by patients who are being treated with immunosuppressants or by those receiving corticosteroid drugs because it can enhance immune system function and interact with drugs that suppress the immune system.[46–84]
Diclofenac sodium 1% gel (Voltaren, also available as a generic). When used for osteoarthritis pain of the hands, elbows or wrists, apply 2 grams to each affected area four times a day (a total of 8 grams per day). When used on knees, ankles, or feet, apply 4 grams to each affected area four times a day (a total of 16 grams per day).  However, the total amount used on your body should not exceed 32 grams per day. A dosing card comes with the gel so you can measure the correct amount.
Schematic showing that when a cell membrane is injured the arachidonic acid pathway is activated to initiate the local inflammatory response through the production of prostaglandins, thromboxanes, and leukotrienes. Their activation requires the enzymes COX and LOX. The NSAIDs can block COX action and thereby prevent the formation of the COX-derived inflammatory mediators. 5-HPETE = 5-hydroperoxyeicosatetraenoic acid; LTC4 = leukotriene C4; PGE2 = prostaglandin E2; PGF2 = prostaglandin F2; PGI2 = prostacyclin; TXA2 = thromboxane.
The power of Luminas pain patches on pain and inflammation has successfully been measured with the help of thermography technology. When inflammation occurs, blood flow is increased in that area, causing the temperatures to rise. This is identifiable on our infrared cameras. Once a Luminas pain patch is applied to the area, you can see it working right away. In as little as 15 minutes, most of the inflammation and pain had disappeared.
You are eligible for a full refund if no ShippingPass-eligible orders have been placed. You cannot receive a refund if you have placed a ShippingPass-eligible order. In this case, the Customer Care team will remove your account from auto-renewal to ensure you are not charged for an additional year and you can continue to use the subscription until the end of your subscription term.

Arnica montana is a flowering mountain herb with a long history of traditional use in pain relief. Arnica extracts contain numerous pain reliefing ingredients, including sesquiterpene lactones, flavonoids which reduce inflammation, swelling and pain, plus thymol which fights infection. Arnica cream, gel and ointment is used to ease muscle pain and spasm, insect bites, superficial burns – including sunburn – sprains and painful joints caused by arthritis or other rheumatic disorders. Herbal arnica products contain measurable levels of active ingredients, while homeopathic arnica products contain lower levels that work in a different way. Research shows that arnica products are as effective at relieving painful joints as ibuprofen gel when applied two to four times a day.


Back pain is one of the most common reasons why people visit a health care provider. The good news is that the pain often goes away on its own, and people usually recover in a week or two. Many people want to stay in bed when their back hurts. For many years, getting bed rest was the normal advice. But current studies recommend no bed rest at all and stress that staying in bed longer than 48 hours not only won’t help but it may, in fact, actually delay your recovery. Here’s why:
The advantage of using a topical analgesic is that the medication works locally. Targeting pain more precisely using a medication applied to the skin can help skirt the side effects of oral drugs. This can be a boon for people whose stomachs are sensitive to NSAIDs. (Keep in mind that a small amount of the medicine still enters the bloodstream and ends up in the stomach and elsewhere, so a topical analgesic isn’t a guarantee against NSAID-related stomach irritation.)
Capsaicin cream, also called capsicum cream, is available in drug stores, health food stores, and online. A typical dosage is 0.025% capsaicin cream applied four times a day. The most common side effect is a stinging or burning sensation in the area. If possible, wear disposable gloves (available at drugstores) before applying the cream. Be careful not to touch the eye area or open skin. A tube or jar of capsaicin cream typically costs between $8 and $25.
You should always consult with a medical professional to get a diagnosis and consultant about treatments, but if they suggest an OTC cream as part of your treatment, there are some good ones to consider. You can find creams with various ingredients and in a variety of formats, including gels, roll-ons, and lotions. Some have a cooling effect, while others bring the heat, and there are scented and unscented options, so it all comes down to preference.
While leading the most vigorous life filled with project deadlines and domestic responsibilities and accomplishing success at all endeavors do you sometimes get compelled to lag behind other such active individuals given to the muscle pain agony? And does this dilemma affect you at a most recurring frequency at times when you are preparing for an office presentation or venturing out to complete household tasks? Be aware that in order to prevail as a most efficient professional and sincere family person putting forward causes of back pain or calf cramp or wrist soreness as reasons for not fulfilling your duties is the least enterprise that you can undertake.
Ensure that the type of anti-inflammatory cream you buy for yourself, a friend, or family member is of the right quality and more efficient in helping you deal with your health predicaments. The best quality brands would be fast acting and gentle to your skin with every application. Most of all, the cream that you choose at any given point in time should not have any side effects otherwise you would be exposing yourself to the ordeal of tackling what would result from using the poor quality creams in hopes of dealing with a minor injury. The best cream would take the shortest period to help relieve you of any kind of pain or inflammation so that you would comfortably carry on with whatever you might be doing.
Enjoy essential oils. Essential oils have long been valued for their analgesic effects in many cultures. There are many ways to benefit from essential oils—some people inhale them (aromatherapy), others include several drops in their massage oil and enjoy as part of a therapeutic massage. Several oils in particular are thought to have an analgesic effect, including peppermint oil, rosemary, and lavender.
Injections. If other measures don't relieve your pain, and if your pain radiates down your leg, your doctor may inject cortisone — an anti-inflammatory medication — or numbing medication into the space around your spinal cord (epidural space). A cortisone injection helps decrease inflammation around the nerve roots, but the pain relief usually lasts less than a few months.
Hi Carol, Sorry to hear you are in such pain. Hopefully the results of the x-ray will show a way forward to solve the problem. You may benefit from physiotherapy to prevent frozen shoulder, or gentle chiropractic manipulation to correct misalignments of tiny joints – this certainly helped my other half who experienced a similar problem. A topical treatment containing capsaicin may help by damping down nerve generated pain. Magnetic therapy and using a heatlamp are other non-drug approaches which have been shown to improve circulation and boost healing of shoulder problems. Anti-inflammatories such as omega-3, turmeric or rosehip are other options. I hope you feel more comfortable soon. Best wishes, Sarah B
I purchased this because it was less expensive than Penetrex and I'd thought I'd try it out.. Unfortunately, compared to Penetrex, at least for me, I do not feel that it is worth the savings. I'm using it for Plantar Fasciitis and Osteoarthritis in my knees. Although it does provide some pain relief, the duration is limited to a couple hours, whereas Penetrex lasts for up to half a day. However, SynthaFlex does offer a little more relief, albeit very temporarily, for my Osteoarthritis than Penetrex does. It is not nearly as effective for my Plantar Fasciitis pain. Ultimately, if I have to apply it many times throughout the day, it is not cost effective in comparison.
Cold and heat therapies. It's best to use cold compresses or an ice pack, not heat, immediately following a back injury, since this can alleviate pain by numbing the area and prevent or reduce swelling. About 48 hours after the onset of back pain, though, applying heating pads or a hot-water bottle to your back may be helpful. The warmth soothes and relaxes aching muscles and increases blood flow, which helps the healing process. Keep in mind that heat therapy is only helpful for the first week.
Hi Carol, Sorry to hear you are in such pain. Hopefully the results of the x-ray will show a way forward to solve the problem. You may benefit from physiotherapy to prevent frozen shoulder, or gentle chiropractic manipulation to correct misalignments of tiny joints – this certainly helped my other half who experienced a similar problem. A topical treatment containing capsaicin may help by damping down nerve generated pain. Magnetic therapy and using a heatlamp are other non-drug approaches which have been shown to improve circulation and boost healing of shoulder problems. Anti-inflammatories such as omega-3, turmeric or rosehip are other options. I hope you feel more comfortable soon. Best wishes, Sarah B
Back pain is one of the most common reasons why people visit a health care provider. The good news is that the pain often goes away on its own, and people usually recover in a week or two. Many people want to stay in bed when their back hurts. For many years, getting bed rest was the normal advice. But current studies recommend no bed rest at all and stress that staying in bed longer than 48 hours not only won’t help but it may, in fact, actually delay your recovery. Here’s why:
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown efficacy in patients with osteoarthritis (OA) pain but are also associated with a dose-dependent risk of gastrointestinal, cardiovascular, hematologic, hepatic, and renal adverse events (AEs). Topical NSAIDs were developed to provide analgesia similar to their oral counterparts with less systemic exposure and fewer serious AEs. Topical NSAIDs have long been available in Europe for the management of OA, and guidelines of the European League Against Rheumatism and the Osteoarthritis Research Society International specify that topical NSAIDs are preferred over oral NSAIDs for patients with knee or hand OA of mild-to-moderate severity, few affected joints, and/or a history of sensitivity to oral NSAIDs.
Those who have tried using this Neosporin product say that cuts and scrapes heal within three days when this ointment is applied and that pain subsides quickly. To properly use the ointment, be sure to first clean the affected area with mild soap or saline water. Apply the Neosporin and then use a bandage to properly protect the area while it heals.
10. Cherries – Due to the presence of compounds called anthocyanins—the same phytonutrients that give cherries their rich ruby hue – you can count on cherries to tamp down pain. Muraleedharan Nair, PhD, says, “They block inflammation and they inhibit pain enzymes, just like aspirin, naproxen, and other nonsteroidal anti-inflammatories.” Cherries are said to have the highest anti-inflammatory content of any food, making them great for remedying issues such as arthritis.
Studies have shown that pycnogenol is 50–100 times more potent than vitamin E in neutralizing free radicals and that it helps to recycle and prolong the activity of vitamins C and E. Studies have shown pycnogenol to be effective in reducing blood pressure and reducing the risk of venous thrombosis by its effect on vascular endothelium. The usual dosage is 100–200 mg daily. Few side effects from the use of pine bark extracts have been reported, the most frequent being mild gastrointestinal effects such as diarrhea and upset stomach. Pycnogenol should not be taken by patients who are being treated with immunosuppressants or by those receiving corticosteroid drugs because it can enhance immune system function and interact with drugs that suppress the immune system.[46–84]
Green tea research now demonstrates both anti-inflammatory and chondroprotective effects. Additionally, green tea research includes the “Asian paradox”, which theorizes that increased green tea consumption in Asia may lead to significant cardiovascular, neuroprotective and cancer prevention properties.[113] The usual recommendation is 3–4 cups of tea a day. Green tea extract has a typical dosage of 300–400 mg. Green tea can cause stomach irritation in some, and because of its caffeine content, a decaffeinated variety is also available; but the polyphenol content is currently unknown.[2,49,53,108,112,117,120]
If you’re sensitive to aspirin, or if you’re taking any over-the-counter (OTC) anti-inflammatory drugs (like aspirin, ibuprofen, or naproxen), you should avoid willow bark. You should also avoid taking it if you’re taking warfarin (Coumadin) or other anticoagulant treatments, as salicin could increase the risk of bleeding. Talk to your doctor before taking willow bark if you’re taking other anti-inflammatory or pain medications.
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