Although it is difficult to establish the mechanism of action of a plant due to the variety of its components, in vitro clinical trials have shown that the anti-inflammatory properties of arnica are based mainly on the inhibition of NF-kappa B transcription factor, which is a key part of the immunological and anti-inflammatory processes. This protein regulates the transcription of various inflammatory cytokines, such as interleukins, as well as that of the genes encoding COX-2 (an enzyme which favours inflammation).
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Curcumin is the bioactive compound in turmeric that gives the herb its healing properties. It’s one of the safest anti-inflammatories you can take, and is an effective natural pain reliever too — even for severe pain. In fact, curcumin matches or outperforms ibuprofen, acetaminophen, and other over-the-counter painkillers without any side effects.[12]
The Biofreeze® pain relief gel is available in 16-, 32-, or 128-ounce bottles and is offered as the colorless or original green formula. The company has been making pain relief products for over 25 years. It is the #1 product that has been clinically used by professional healthcare hands-on providers, massage therapists, physical therapists, chiropractors, foot doctors (podiatrists), athletic coaches, instructors, and trainers. This is considered the best pain relief cream for muscle pain perfect for athletes. When professionals have over a hundred clients each week, the economical 128-ounce jug might be best for you for not running out. You always want it on hand for clients with sore aching body parts.

in December 1998, celecoxib (Celebrex) was approved by the Food and Drug Administration (FDA) as the first selective COX-2 inhibitor for treatment of arthritis pain.[92,13,22] Rofecoxib (Vioxx) was approved several months later, followed by valdecoxib (Bextra).[92,28,67,79] These NSAIDs were designed to allow continued production of the gastrointestinally protective prostaglandins produced through the COX-1 enzyme system while blocking the COX-2 enzyme that produces the inflammatory prostaglandins.[34,45,51,89]


Green tea research now demonstrates both anti-inflammatory and chondroprotective effects. Additionally, green tea research includes the “Asian paradox”, which theorizes that increased green tea consumption in Asia may lead to significant cardiovascular, neuroprotective and cancer prevention properties.[113] The usual recommendation is 3–4 cups of tea a day. Green tea extract has a typical dosage of 300–400 mg. Green tea can cause stomach irritation in some, and because of its caffeine content, a decaffeinated variety is also available; but the polyphenol content is currently unknown.[2,49,53,108,112,117,120]
Voltaren® Gel (topical diclofenac) is a particularly safe and useful medicine. It’s an anti-inflammatory cream, so it can be applied only where you need it, instead of soaking your entire system with a medication, avoiding or dramatically reducing common side effects like indigestion, as well as some serious safety concerns associated with oral diclofenac. In the US, this drug is FDA-approved to treat osteoarthritis in “joints amenable to topical treatment, such as the knees and those of the hands,” but it probably also works for some other painful problems, such as some repetitive strain injuries and back pain. The evidence shows that it “provides clinically meaningful analgesia.” So this product actually works and gets a pass from skeptics and critics — a rare thing in the world of pain treatments!
Prostaglandins act as short-lived localized hormones that can be released by any cell of the body during tissue, chemical, or traumatic injury, and can induce fever, inflammation, and pain, once they are present in the intercellular space. Thromboxanes, which are also hormone activators, can regulate blood vessel tone, platelet aggregation, and clot formation to increase the inflammatory response.[92,82] The inflammatory pathway is a complex biochemical pathway which, once stimulated by injury, leads to the production of these and other inflammatory mediators whose initial effect is pain and tissue destruction, followed by healing and recovery.[34,51] A major component of the inflammatory pathway is called the arachidonic acid pathway because arachidonic acid is immediately released from traumatized cellular membranes. Membrane-based arachidonic acid is transformed into prostaglandins and thromboxanes partly through the enzymatic action of cyclooxygenase (COX)[34,57]. There are two types of COX enzymes, COX-1 and COX-2. Both the enzymes act similarly, but selective inhibition (as accomplished by selective COX-2 inhibiting NSAIDs) can make a difference in terms of side effects.

An ayurvedic spice known to tame arthritis pain, the curry spice turmeric contains an antioxidant compound called curcumin. In an animal-based study published in 2007, scientists discovered that curcumin can overpower pro-inflammatory proteins called cytokines. The compound may also help decrease pain associated with autoimmune disorders and tendonitis.
Arnica is a natural anti-inflammatory, which is why you’ll find it in many pain relief gels and creams. It is a powerful natural medicine that comes from the perennial flower Arnica Montana. It that makes natural quick and easy pain relief possible, and it is also one of the biggest reasons why most pain relief gels and creams that use Arnica are available over the counter without a prescription or a doctor’s visit.
My doctor reddened and paniced a bit when he took my B/P and blamed it on the tablets which I rarely took, but the gel had been increased due to a worsening scoliosis and and a damaged knee getting worse with age. Recent research states clearly that this is a serious side effect, and it was not just a small rise but one of 25-30 points on my normal B/P!!! It can also cause hardening of the arteries and eventually a heart attack.
Cayenne pepper is also a potent candida killer. Scientists found it’s active against 16 different fungal strains, including candida, a common internal infection linked to joint pain, among other candida symptoms. (1) Cayenne also provides external pain relieve. Capsaicin, an important natural painkiller found in cayenne, helps treat muscle soreness, tension and even skin infections. Look for it in natural painkilling creams.
Because drugs, unlike natural remedies for inflammation and pain, are created in a lab and our bodies are not equipped to digest and process them. Moreover, drugs are incredibly powerful which gives them the ability to offer fast relief of symptoms, like pain and inflammation. This is good for short-term use, but can be harmful over time. The body just can’t metabolize these drugs sufficiently to prevent them causing new damage and side effects.
Performance Health®, Bon Vital'®, Biofreeze®, BVspa™, TheraBand®, the Color Pyramid Design™ and Associated Colors™, TheraPearl®, Hygenic®, Pedigenix®, Prossage®, Active Ankle® and Cramer® trademarks are property of Performance Health and/or its subsidiaries and may be registered in the United States and other countries. Unauthorized use is strictly prohibited. ©2017 Performance Health. All rights reserved.
Yes, most of these creams can either be used on a daily basis or long-term basis. Nevertheless, at any given point in time, always ensure that you consult with your doctor to find out how often it would be advisable to use such forms of medication. The best quality ones are the ones that would be FDA approved and natural. Therefore, you should use these types of medication for as long as the health practitioners advise.

4. Devil’s Claw (Harpagophytum procumbens) – This ominous sounding herb is actually great for treating numerous health conditions, among them are liver problems and heart burn. It also has anti-inflammatory effects and can reduce pain from arthritis, headaches, and low back discomfort. The University of Maryland Medical Center has published several studies that had great success treating Osteoarthritis with Devil’s Claw.


Physical therapists use PEMF to heal fractures and torn cartilage faster, and surgeons recommend it as a post-op way to minimize soft tissue inflammation.[20][21] I use it to recover from workouts faster and keep inflammation low. PEMF machines send electromagnetic pulses through your tissue, gently stimulating anti-inflammatory and repair compounds.
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