7) The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. Li M, Bolduc AR, Hoda MN, Gamble DN, Dolisca SB, Bolduc AK, Hoang K, Ashley C, McCall D, Rojiani AM, Maria BL, Rixe O, MacDonald TJ, Heeger PS, Mellor AL, Munn DH, Johnson TS. J Immunother Cancer. 2014 Jul 7; PMID: 25054064
Hi Peggy, It’s not a treatment with which I am familiar. Looking at the incredients, Blue Ice contains alcohol which will cool by evaporating, an aspirin-like substance (methyl salicylate), magnesium (muscle relaxant) and capsicum which has a pain killing action by depleting nerve endings of nerve chemicals. It looks like it is effective for muscle and joint pain and has good reviews but I can’t speak from personal experience. Hope that helps, Sarah B

Enjoy essential oils. Essential oils have long been valued for their analgesic effects in many cultures. There are many ways to benefit from essential oils—some people inhale them (aromatherapy), others include several drops in their massage oil and enjoy as part of a therapeutic massage. Several oils in particular are thought to have an analgesic effect, including peppermint oil, rosemary, and lavender.
Think of Voltaren® Gel as “ibuprofen in a gel.” (It’s actually diclofenac, but ibuprofen is a much more familiar drug name in North America, where the product is still fairly new, and available only with a prescription in the US.) It’s a topical anti-inflammatory medication,NSAID“Non-steroidal anti-inflammatory drug,” usually pronounced “en-sed.” and FDA-approved to treat osteoarthritis in “joints amenable to topical treatment, such as the knees and those of the hands.” The evidence shows that it “provides clinically meaningful analgesia.”1 This is an appealing treatment idea that actually works reasonably well: what a pleasure to be able to say that!2
While there are mixed answers on how many servings of leafy greens one should eat each day for preventive effects, an overall eight to ten servings of vegetables and fruits daily is recommended for the best results. Of those, perhaps two to three servings of vegetables should be leafy greens. Leafy greens are rich in quercetin, a type of flavonoid that is responsible for broad anti-inflammatory benefits, as well as vitamin C, vitamin K, and essential minerals like magnesium. (15)
5. Birch Leaf (Betula Lenta) – The leaves from the Birch tree act much like cortisone, a prescription drug used to treat endocrine disorders, arthritis, lupus, skin disease, autoimmune disorders, and more. A main chemical compound found in Birch leaves is methyl salicylate, similar to salicylic acid used in aspirin. It is anti-spasmodic, analgesic, astringent, antifungal, diuretic, detoxifying, reduces oxidative damage to skin (stopping wrinkles), and enhances circulation. It also promotes enzymatic secretions in the body. It is truly one of the first powerful pain-relievers ever used.
I purchased this because it was less expensive than Penetrex and I'd thought I'd try it out.. Unfortunately, compared to Penetrex, at least for me, I do not feel that it is worth the savings. I'm using it for Plantar Fasciitis and Osteoarthritis in my knees. Although it does provide some pain relief, the duration is limited to a couple hours, whereas Penetrex lasts for up to half a day. However, SynthaFlex does offer a little more relief, albeit very temporarily, for my Osteoarthritis than Penetrex does. It is not nearly as effective for my Plantar Fasciitis pain. Ultimately, if I have to apply it many times throughout the day, it is not cost effective in comparison.
People with sensitive skin, infants, children, pregnant women, and seniors might be at a higher use using these products. People with kidney problems or kidney failure in the past shouldn’t try an Ibuprofen cream. If you take aspirin, prescribed blood thinners such as Coumadin (warfarin) or have bleeding of the gastrointestinal tract, consult your healthcare provider before using these topical pain products. Do not use salicylates that cause blood to be thinner.
15. Bromelain – This natural pain-reducer comes from the enzymes present in pineapple stems. Research shows that it reduces levels of prostaglandins, which are hormones that induce inflammation. Bromelain may benefit people with arthritis and conditions marked by musculoskeletal tension (like TMJ syndrome), in addition to those suffering trauma-related inflammation. The enzyme also promotes healing in muscles and connective tissues.
Customers say that while they were skeptical at first, they are pleasantly surprised by just how well this lotion from Two Old Goats works to relieve arthritis pain. Its name come from its key ingredient—goat’s milk—which is blended with essential oils, including lavender, rosemary, peppermint, and eucalyptus in a formula designed to penetrate deep into your joints and muscles. All those oils also act as a moisturizer so it keeps your skin looking great too, and the pump bottle makes it easy to dispense.
“For years I have suffered with sciatica pain going down my right side. It is so painful that even sitting hurts. Nothing has ever worked well. I tried your patches by putting 3 discs on the painful area. For 3 days, I was pain free. As you suggested, I replaced the patches with new ones after 3 days and it no longer hurts. I also used it on my shoulder after a fall. It works! Thank you for helping me find relief.” – Norma M.
While adding turmeric as a spice to foods tastes good, it has to be eaten in pretty large quantities to get a medicinal effect, as our gut does not absorb it well. The maximum pain relief effects are usually found with supplements that contain curcumin optimized for absorption (such as curcumin phosphatidylcholine complex). I like Meriva by Thorne Research, typical dosage of 500-1000mg twice daily. Although curcumin is much safer than anti-inflammatory medications, it does have some mild blood-thinning effects, so make sure to ask your health care provider before starting supplementation.
Since the time of Hippocrates white willow bark has been in use as a natural means of reducing inflammation and pain, specifically associated with osteoarthritis and rheumatoid arthritis, as well as headache, backache, gout and PMS. The bark of the willow tree contains the chemical salicin, which has a similar effect in the body as acetylsalicylic acid (aspirin). But it’s better than aspirin, because it has none of the gastrointestinal side effects, and it naturally contains flavonoids (anti-inflammatory compounds found in plants).
Pain is a leading cause of insomnia—difficulty with falling asleep and/or staying asleep. Approximately two-thirds of people with chronic back pain suffer from some type of sleep disorder. Paradoxically, inadequate sleep can make your back pain worse. This vicious cycle makes it ineffective to treat just the pain. If you have sleep problems, you need to get the sleep problems addressed too.

Arnica is a natural anti-inflammatory, which is why you’ll find it in many pain relief gels and creams. It is a powerful natural medicine that comes from the perennial flower Arnica Montana. It that makes natural quick and easy pain relief possible, and it is also one of the biggest reasons why most pain relief gels and creams that use Arnica are available over the counter without a prescription or a doctor’s visit.
Note: The cream is hot to your skin and should be used with caution. The heat comes from capsicum (capsicum annuum) oleoresin a hot pepper. Try a small amount the first time at your inside wrist and wait a half hour to see how it feels. Do not bathe or shower after putting it on because that will only make you feel hotter. Let your body cool down first. Never put the cream near your eyes or mucous membranes such at the lower nose. Do not use on your private area. Wash your hands after you have rubbed the cream into your skin.
Back pain is a health concern for most people in the United States at some point in their lives and one of the most common reasons people miss work or visit the doctor. More than 80 percent of Americans will experience low back pain, and this health problem costs the United States over $100 billion each year, most of which is a result of lost wages. 
Ongoing pain can wreak havoc on your life, affecting your cherished relationships, finances, and your ability to get stuff done at work and at home. It can also interrupt your sleep and affect your mood. Because many other problems commonly occur along with chronic lower back pain, anything you can do for yourself that is a natural anti-depressant will help.

Acetylsalicylic acid works by irreversibly disabling the COX enzymes to block the cascade [Figure 1]. NSAIDs have evolved from blocking both COX-1 and COX-2 to selectively only blocking COX-2 in order to inhibit the inflammatory response and reduce the production of inflammatory prostaglandins and thromboxanes. The major push to develop the selective COX-2 inhibitors has been the recognition of significant complications associated with the nonselective COX-1 and COX-2 NSAIDs. Nonselective NSAIDs’ major side effects include significant gastrointestinal upset, gastritis, ulceration, hemorrhage, and even death. By locking COX-1, which also normally acts to protect the gastrointestinal mucosa, nonselective NSAIDs and aspirin can cause significant gastric tissue damage.[34,51,78,91,3,101,115]
SAMe is one of the natural chemicals made within the body that science has been able to duplicate in a lab, and make into a supplement. Studies have shown SAMe supplementation to be comparable to the pain-relieving effects of Celebrex by the second month of taking the product, without the side effects. The SAMe chemical has a role in pain, depression, liver disease and has been shown effective when used for relieving the symptoms of osteoarthritis, fibromyalgia, bursitis, Alzheimer’s disease, multiple sclerosis (MS), migraine headache, depression and more, making it a great natural remedy for inflammation.
A lot of people who read this are going to want to try it on their low back pain, neck pain, and/or other kinds of muscle pain. Will it work? The only honest answer is, “Who knows?” I have no clinical experience with this yet, and certainly it’s unstudied. It might be worth trying, in moderation, with the full awareness that there’s every possibility that it could be a waste of time and money.
Turmeric can be consumed in a variety of forms, including as a spice added to foods or drinks and encapsulated for those who are not tolerant of the signature spicy taste. Two to three teaspoons of turmeric daily can help to provide therapeutic levels of relief and preventive benefits with little side effects. Note: Turmeric absorbs best when taken in combination with black pepper (approximately 1/4 teaspoon of black pepper for every 1 teaspoon of turmeric). (17)
you should know that you should not apply sunscreens, cosmetics, lotions, moisturizers, insect repellents, or other topical medications to areas treated with diclofenac gel (Voltaren). If you have been prescribed diclofenac liquid (Pennsaid), wait until the area of application is completely dry before applying any of these products or other substances.
Topical anti-inflammatories work in the same way but, instead of having an effect on all of the body, they only work on the area to which you have applied them. When they are applied they are taken into (absorbed into) your skin. They then move deeper into areas of the body where there is inflammation (for example, your muscle). They relieve pain and reduce swelling affecting joints and muscles when rubbed into the skin over the affected area. Using a topical preparation means that the total amount of anti-inflammatory in your body is very low. This in turn means that you are much less likely to have a side-effect to this medicine.
After an injury, first rest, ice the area, use compression, and elevate the area. The acronym to help you remember is RICE. Rest the area. Ice the area 4 times a day for 10 to 15 minutes. If it looks better, compress the area with an Ace-type elastic bandage. To reduce swelling, ice helps, and so does elevating the area above your heart. When the swelling is down but you still have mild pain, apply a topical cream or gel according to the package directions. If it has worsened, consult your doctor.
Almost every person with fibromyalgia describes their muscles as tight and full of painful muscle knots called trigger points. After I was diagnosed with fibromyalgia during medical school, I tried many different styles of massage, but got no benefit until I found a specialized technique called myofascial release pioneered by John Barnes, PT. This form of massage therapy involves using very slow but sustained gentle pressure to separate tiny adhesions in the muscle tissue and fascia, and this lessens muscle tension and gently breaks up knots in the connective tissue (to learn more about the vital importance of fascia in fibromyalgia, read my previous blog post). Two European studies found that myofascial release therapy was effective for reducing fibromyalgia pain, and that it gave long-lasting pain relief even at one month and six months after the last session. To find a John Barnes-trained therapist skilled in this technique go to www.mfrtherapists.com.
The benefits of heat therapy are twofold: it increases the flow of healing oxygen and nutrients to the damaged area, and it suppresses pain signals. Some find that wearing a heat wrap, such as those from ThermaCare, is best because it releases a low level heat for several hours and can be worn under clothes so you can remain mobile. You can also combine the benefits of aromatherapy and a heat by adding an essential oil to the hot pack; you can experiment by making your own microwaveable heating pad at home and adding different essential oils to see what works best for you.
Or how can we select the best pain relief cream for back pain that has no harmful side effects and works fast? But the best pain relief cream is such a remedy that relieves you from any kind of chronic pains. They are offering you a cooling sensation in the affected area. It also comes with a pleasant scent which is also known as the best pain relief cream for knees as well.
A key warning about using topical analgesics: don’t use them if you are also taking an oral NSAID—either prescription or over-the-counter—without telling your doctor. Taking too much of an NSAID can land you in the hospital with stomach bleeding or an ulcer flare-up. In fact, up to 100,000 Americans are hospitalized every year for NSAID-related gastrointestinal problems.

Last year, I suffered a severe attack of gouty arthritis. I was crying in pain and tried several pain killers without any effect. Then, I consulted my doctor. He told me to not take any pain killers and prescribed Generic Colchicine 0.5mg no rx instead. And thankfully, the pain started subsiding. I would like to recommend this medicine to all patients suffering from gouty arthritis.
Rosenzweig, S., Greeson, J. M., Reibel, D. K., Green, J. S., Jasser, S. A., & Beasley, D. (2010, January). Mindfulness-based stress reduction for chronic pain conditions: Variation in treatment outcomes and role of home meditation practice. Journal of Psychosomatic Research, 68(1), 29–36. Retrieved from https://www.sciencedirect.com/science/article/pii/S0022399909000944
There is nothing worse than having to wait for your pain medication to kick in when you’re in a bad way, only for it to wear off in a few short hours once it does start to work. What you need in these times is fast pain relief that acts fast and lasts for several hours. Thanks to the LUMINAS Pain Relief Patch, this is now possible, even without the use of harmful drugs.
The powerful anti-inflammatory ginger is more effective than drugs like ibuprofen for pain relief, according to a 2013 study published in the journal Arthritis. The study revealed that drugs like Tylenol or Advil do block the formation of inflammatory compounds. Ginger, however, “blocks the formation of the inflammatory compounds–prostaglandins and leukotrienes–and also has antioxidant effects that break down existing inflammation and acidity in the fluid within the joints,” reported care2.com.
×