Chondroitin sulphate chains bind to hyaluronic acid to form ‘springy’ molecules that increase the strength and elasticity of cartilage, making it more resilient. Chondroitin also acts as a signal to inhibit the enzymes responsible for breaking down cartilage, and to increase the production of collagen. Chondroitin is therefore an ideal complement to glucosamine and the two are often combined in joint and muscle pain relief creams.


Side effects from topical medications include redness, itching, and other skin irritation. They are generally mild—and uncommon. The cause of skin irritation is often the material used to make the cream or gel, not the NSAID, says Dr. Joanne Borg-Stein, medical director of the Harvard-affiliated Spaulding-Wellesley Rehabilitation Center in Massachusetts. When that happens, it’s possible for a pharmacist to create a preparation with ingredients that are less irritating to your skin.


Finally, the active ingredients within a pain relief cream interact with local nerve endings to damp down inflammation, reduce pain and swelling and ease stiffness. All these different actions make topical, rub-in creams and gels highly effective for treating painful joints, sore muscles and sport injuries. Here, I’ve reviewed what I believe are the best pain relief creams, sore muscle creams and pain relief gels.
One way to increase the effectiveness of Biofreeze is to add it to a massage! And what do professional massage therapists use in their practice regularly? Creams and oils to help their hands glide across the skin and focus on relieving pain. External pain relief creams can be used as a part of your at-home massage to not only enhance your comfort, but to soak in and relieve any residual pain.
There's a reason there are so many roll-ons on this list. They're super handy and easy to use. This CobraZol gel provides quick relief that lasts up to 10 hours. It's a good choice for both chronic and acute pain. This gel comes in a 2 oz format. Believe it or not, this stuff actually contains cobra venom. Venom apparently is thought to help de-active pain pathways and reduce pain. This roll-on is a great way to manage pain and help users wean off of more serious and potentially dangerous pain medications.
Meditation has been proven to reduce chronic pain in several scientific studies. Research from Duke University found that people suffering from chronic back pain saw significant reductions in pain and psychological distress after practicing a form of meditation that focuses on releasing anger. In another study, meditators experienced a 40% reduction in pain intensity.
The only side effect most of these products have is odor. Some of them were reviewed as being neutral to actually smelling good, while others were reported to have quite a strong smell you might not like. A lot of this has to do with the nature of the ingredients in pain relieving treatments. Mentholated ingredients give natural relief, but they do tend to have a strong odor that accompanies them.
Acetylsalicylic acid works by irreversibly disabling the COX enzymes to block the cascade [Figure 1]. NSAIDs have evolved from blocking both COX-1 and COX-2 to selectively only blocking COX-2 in order to inhibit the inflammatory response and reduce the production of inflammatory prostaglandins and thromboxanes. The major push to develop the selective COX-2 inhibitors has been the recognition of significant complications associated with the nonselective COX-1 and COX-2 NSAIDs. Nonselective NSAIDs’ major side effects include significant gastrointestinal upset, gastritis, ulceration, hemorrhage, and even death. By locking COX-1, which also normally acts to protect the gastrointestinal mucosa, nonselective NSAIDs and aspirin can cause significant gastric tissue damage.[34,51,78,91,3,101,115]
Our writers spent 5 hours researching the most popular arthritis creams on the market. Before making their final recommendations, they considered 30 different creams overall, screened options from 20 different brands and manufacturers, read over 50 user reviews (both positive and negative), and tested 1 of the creams themselves. All of this research adds up to recommendations you can trust.
Chronic pain is a modern day epidemic that affects more than 1.5 billion people worldwide.  It costs nations billions of dollars in lost productivity and medical expenses every year. Debilitating pain effects more individuals than heart disease, cancer and diabetes combined.   Doctors throw drug after drug at these pain syndromes with very little long-term success.  Here are some of the best natural agents to reduce pain.
For a 2006 report published in Rheumatology, investigators analyzed the available research on the use of balneotherapy in treatment of low back pain. Looking at five clinical trials, the report's authors found "encouraging evidence" suggesting that balneotherapy may be effective for treating patients with low back pain. Noting that supporting data are scarce, the authors call for larger-scale trials on balneotherapy and low back pain.
Still an excellent product. It remains effective for pain relief for about 5 hours with each application for me. Make sure to rub in a good thick portion for several minutes to the entire area of pain. Each jar of Synthaflex lasts about 18 days for me with applications twice each day. It remains the best external joint and muscle pain relief rub that I have ever used.

“I finally found relief. I've got fibromyalgia and I'm always in pain. I tried Relief because it says, "Chiropractor recommended," so what did I have to lose. This was the BEST chance I ever took!! I'm so happy I ordered this. I will be a customer for life as long as it works. I'm sold. I've got nothing but GREAT things to say about this cream. It does exactly what it's called, it gives you relief. Thank you SO MUCH :)" *


While adding turmeric as a spice to foods tastes good, it has to be eaten in pretty large quantities to get a medicinal effect, as our gut does not absorb it well. The maximum pain relief effects are usually found with supplements that contain curcumin optimized for absorption (such as curcumin phosphatidylcholine complex). I like Meriva by Thorne Research, typical dosage of 500-1000mg twice daily. Although curcumin is much safer than anti-inflammatory medications, it does have some mild blood-thinning effects, so make sure to ask your health care provider before starting supplementation.


This product has a huge market universally. It is used by more than 2 million individuals because of how effective it is in relieving pain and minimizing inflammation. Penetrex has been amongst the most renowned pain relief drugs for quite some time over the years and it is still being used widely that is why acquiring one for yourself would serve your needs greatly.
Hallie Levine is an award-winning magazine and freelance writer who contributes to Consumer Reports on health and fitness topics. Her work has been published in Health, Prevention, Reader's Digest, and Parents, among others. She's a mom to three kids and a fat but feisty black Labrador Retriever named Ivry. In her (nonexistent) spare time, she likes to read, swim, and run marathons.

Whether due to a challenging session at the gym or normal wear and tear associated with aging, back pain shouldn’t impair your daily activities. Finding the best pain relief cream for back pain is easy with the array of back creams for pain available. You can deal with back stiffness and soreness quickly and with minimal fuss. Instead of over-the-counter pills, try these ointments for back pain.
In addition to the other methods and strategies discussed throughout my book, I recommend taking natural remedies that reduce pain and inflammation, protect joint health and promote healing without side effects. Below I offer an overview of 20 different supplements formulas or ingredients often found within such formulations. Read each, keeping in mind your specific condition and how some may be more effective for you than others.
Over-the-counter (OTC) pain relievers. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), might relieve acute back pain. Take these medications only as directed by your doctor. Overuse can cause serious side effects. If OTC pain relievers don't relieve your pain, your doctor might suggest prescription NSAIDs.
If you’ve been suffering from pain, whether it is due to arthritis, migraines, or back pain, its time to get started finding relief today. Try out some of the herbal remedies listed above, and combine those with mind-body therapies that can help you gain control over your pain. Make sure to be getting good, regular sleep, which will also help in decreasing your pain levels.[17] If you still don’t find relief, try infrared or ozone therapy treatments.

I am a science writer, former massage therapist, and I was the assistant editor at ScienceBasedMedicine.org for several years. I have had my share of injuries and pain challenges as a runner and ultimate player. My wife and I live in downtown Vancouver, Canada. See my full bio and qualifications, or my blog, Writerly. You might run into me on Facebook or Twitter.

Topical non-steroidal anti-inflammatories (often abbreviated to NSAIDs) are creams, gels, rubs, solutions or sprays that contain a nonsteroidal anti-inflammatory agent and are designed to be applied directly to the skin overlying a painful joint or area of bone. They are used to relieve pain and to treat symptoms of arthritis such as inflammation, swelling, and stiffness. Topical NSAIDs may also be used in the treatment of actinic keratosis (a precancerous patch of thick, scaly or crusted skin).

People with sensitive skin, infants, children, pregnant women, and seniors might be at a higher use using these products. People with kidney problems or kidney failure in the past shouldn’t try an Ibuprofen cream. If you take aspirin, prescribed blood thinners such as Coumadin (warfarin) or have bleeding of the gastrointestinal tract, consult your healthcare provider before using these topical pain products. Do not use salicylates that cause blood to be thinner.
When you suffer from recurring back pain, the last thing you want to do is become dependent on medication. Dr. Pat’s Ultra Freeze gel is a simple, non-intrusive solution to muscle aches and soreness that gets to work straight away, helping you get on with your daily life without pain. Designed to combat discomfort associated with arthritis and sciatica as well as muscle pain, the cooling gel comes in a larger than average container, meaning you can depend on it being there when you need it.
“I was first introduced to Relief by my Chiropractor after I pulled a muscle. Later my son, while playing hockey, received a very nasty hit during a game and was given Biofreeze as part of his recovery process. I can tell you Relief is 10x better—he was still in pain after using the Biofreeze, so I grabbed the Relief and he could not believe the difference. Now we are a Relief ONLY household. I am spreading the word to all the other hockey mom’s on the quality of your product and how well it works. Thank you for creating Relief and keep up the good work.” *
I’ve just emphasized that Voltaren is mainly appropriate for shallow inflammation, but there is some evidence that Voltaren might be able to “reach deeper.” This is hardly the stuff of medical certainty yet, but researchers Huang et al found that Voltaren treated pain coming from deep inside the spine, right in the centre.6 They concluded that it could be a “convenient and safe clinical intervention” for a few types of back pain. An anti-inflammatory gel will likely fail with many kinds of back pain, but there’s also virtually no down-side to trying. See my low back pain tutorial for extremely detailed information about medications for back pain.
In October 2007, diclofenac sodium 1% gel (Voltaren Gel) became the first topical NSAID for OA therapy approved in the United States following a long history of use internationally. Topical diclofenac sodium 1% gel delivers effective diclofenac concentrations in the affected joint with limited systemic exposure. Clinical trial data suggest that diclofenac sodium 1% gel provides clinically meaningful analgesia in OA patients with a low incidence of systemic AEs.
It’s estimated that up to 80 percent of adults experience persistent symptoms of lower back pain at some point in their lives, and about 31 million Americans struggle with the condition at any given time. Given its extremely high prevalence rate — whether due to a weak psoas muscle, sciatic nerve pain or some other cause — it’s not surprising that lower back pain is considered the single leading cause of disability worldwide according to the American Chiropractic Association, with half of all American workers reporting having occasional back troubles each year. (1) Naturally, this leads to millions searching for lower back pain relief.
Carun Active Hemp Ointment is an infusion of cannabidiol CBD in petroleum jelly, hemp seed oil and olive oil, and is scented with a blend of natural lemon, peppermint and lavender essential oils. This ointment contains CBD at a strength of 3% (a 100ml pot contains 300mg CBD) and has a soft, melting texture at room temperature. Carun Active Hemp Ointment is available from Amazon.co.uk. A wide range of CBD ointments and creams are also available on Amazon.com some of which combine CBD with Arnica for additional healing benefits.
Talking about your back pain with a therapist may bring some relief. In a UK study, back pain sufferers who had 90 minutes of group cognitive behavioral therapy a week for six weeks reported less pain during the treatment. (Cognitive behavioral therapy focuses on solving problems by changing thoughts and behavior.) A year later, 59% said their pain was totally cured, compared to just 31% in the group that did not go through therapy.
To avoid unwanted weight gain, consuming inflammatory ingredients or complications due to nutrient deficiencies, reduce or eliminate the following foods: added sugar, sweetened beverages or snacks, refined vegetable oils, refined grain products, too much alcohol and tobacco products (smoking impairs blood flow and adds to nutrient deprivation to spinal tissues).
Chondroitin sulphate is produced naturally in the body to promote the formation of healthy cartilage, tendons and ligaments, and it is also an important component of joint synovial fluid. As you get older, your joint cells secrete less and less chondroitin and this has been linked with reduced cartilage quality and the start of degenerative changes.
Cold and heat therapies. It's best to use cold compresses or an ice pack, not heat, immediately following a back injury, since this can alleviate pain by numbing the area and prevent or reduce swelling. About 48 hours after the onset of back pain, though, applying heating pads or a hot-water bottle to your back may be helpful. The warmth soothes and relaxes aching muscles and increases blood flow, which helps the healing process. Keep in mind that heat therapy is only helpful for the first week.

Although it is difficult to establish the mechanism of action of a plant due to the variety of its components, in vitro clinical trials have shown that the anti-inflammatory properties of arnica are based mainly on the inhibition of NF-kappa B transcription factor, which is a key part of the immunological and anti-inflammatory processes. This protein regulates the transcription of various inflammatory cytokines, such as interleukins, as well as that of the genes encoding COX-2 (an enzyme which favours inflammation).
Over-the-counter (OTC) pain relievers. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), might relieve acute back pain. Take these medications only as directed by your doctor. Overuse can cause serious side effects. If OTC pain relievers don't relieve your pain, your doctor might suggest prescription NSAIDs.

Never use a topical product if you have open wounds, scratches, or broken skin to reduce risks. You don’t want to cover up these with Band-Aids. Never apply near your eyes or mucous membranes, including your private area. Be sure to follow the directions on the product. Using these products for too long can make you skin become sensitive and you might have an allergic reaction. If you use a patch and it starts to itch, burn, or your skin has a rash or is red, stop using it. You can use the product for a long time before your body becomes sensitive to one or more of the ingredients. If you have a reaction, see your healthcare provider at once. This can also happen with lotions, creams, sticks, roll-ons, and gels. Don’t keep adding more to your skin if the product doesn’t seem to work. More is not better.
Talking about your back pain with a therapist may bring some relief. In a UK study, back pain sufferers who had 90 minutes of group cognitive behavioral therapy a week for six weeks reported less pain during the treatment. (Cognitive behavioral therapy focuses on solving problems by changing thoughts and behavior.) A year later, 59% said their pain was totally cured, compared to just 31% in the group that did not go through therapy.
In the case of topical creams, many individuals may suffer from allergies that they weren't even aware of until they encounter a negative reaction. These reactions can range in severity from mild skin irritation to more severe issues such as inflammation and increased pain. Remember to check all the ingredients for any topical medication you buy in order to avoid potential allergens and irritants.
When used together, menthol and methly salicylate create vasodilation (opening of the blood vessels) close to the surface of the skin.  Increased blood flow to the area of application is said to have pain-killing on the nerve receptors in the treated area.  When combined, these two ingredients also work together to form a class of treatment called counterirritants. Counterirritants work by tricking the body into feeling sensations other than pain. The menthol and methyl salicylate in muscle creams create conflicting feelings of warmth and cold. When the nervous system sends both of these sensations, at the same time, they compete with and ultimately block pain signals from travelling to the brain.  Together these ingredients, when delivered in muscle creams or sports balms, work to create a powerful 1-2 punch, killing pain and providing relief to aching muscles and joints.
If you are suffering from greatly with different types of pain such as muscle pain or back pain or knee pain etc then having the best pain relief cream seems to be a smart solution. The best pain relief gel or cream or spray will definitely reduce your pain and gives you soothing sensation. When you lessen your chronic pain by using the best pain relief spray or cream, you can sleep and wake up more comfortably.
After reviewing data regarding various treatments for lower back pain, the Agency for Health Care Research and Quality concluded that those suffering from back pain should first try conservative/natural treatments and then consider other options for lower back pain relief if pain persists. Oftentimes low back pain sufferers can find relief naturally by making changes to their lifestyles (including sleep, physical activity, stress and body weight) before choosing more intensive care options.
“For most people, it means their back hurts,” says Richard A. Deyo, MD, MPH,the Kaiser-Permanente Endowed Professor of Evidence-Based Medicine in the department of family medicine at Oregon Health & Science University in Portland. “But it’s often impossible to know the precise anatomical cause of back pain because the back has so many sources of pain.”
MSM is a potent sulfur naturally found in plants, animals and humans that helps rebuild the connective tissue in your joints and is a powerful natural remedy for inflammation and pain. What’s more, MSM has the unique ability to improve cell permeability. This allows harmful toxins to flow out, while allowing health boosting nutrients to flow in to feed your joints, cartilage and connective tissue. It is used for hundreds of symptoms related to a myriad of health diseases and conditions, and is especially effective as a natural remedy for relieving inflammation for improved joint function, and pain associated with joint inflammation, osteoarthritis, rheumatoid arthritis, osteoporosis and tendonitis. One study published in the Journal of AntiAging Medicine found that MSM provides an 80 percent greater reduction in pain compared to the placebo.
A study involving 120 people with acute upper or lower back pain showed that rubbing in comfrey cream, three times a day for 4 to 6 days, reduced pain intensity by 95%, compared with just 38% reduction for inactive ‘placebo’ cream. Comfrey works quickly, providing good pain relief within an hour of application. In fact, researchers have found that comfrey cream is more effective than a prescribed, non-steroidal anti-inflammatory treatment (diclofenac gel) for treating ankle sprains.
With more than 23,000 reviews on Amazon, customers give Penetrex sky-high marks for effective pain relief. If it doesn’t work for you, it comes with a 100 percent, no-questions-asked, money-back guarantee. Formulated to fight inflammation, it contains a mix of ingredients including arnica, choline, glucosamine, Vitamin B6, and MSM. It’s not odor-free, but rather has a light scent that disappears quickly after you apply it. You can use it alone or in conjunction with heating pads, massagers, ice, and other therapies.

Prolotherapy treatments work by naturally promoting a minor inflammatory response near damaged connective tissue, promoting regeneration and the growth of new, healthier tissue in the process. These treatments have been used to effectively reduce or heal chronic musculoskeletal conditions of the back, such as herniated/bulging discs, arthritis, osteoarthritis or other chronic joint pains, and tendonitis that affects the lower body and causes compensations in the spine. (7) For the most benefits, it seems that prolotherapy works best when combined with other back pain treatments, such as spinal manipulation, exercise and in some cases medications when needed.
Inflammatory disorders specifically respond well to the natural collagen-containing gelatin that is found in true bone broth. (24) Bone broth and meat stock are different, since bone broth extracts nutrients from the bones, such as gelatin, minerals, and amino acids, whereas stock only contains nutrients from the meat. While both can be healthy, stock contains no pain-relieving properties.
8. Capsaicin (Capsicum) – Found in hot chile peppers, this natural remedy does wonders for pain. Capsaicin, the active pain-reducing ingredient, temporarily desensitizes nerve receptors called C-fibers which cause the pain response. Capsaicin also diminishes soreness for 3 to 5 weeks while the C-fibers regain sensation. A single 60-min application in patients with neuropathic pain produced effective pain relief for up to 12 weeks. Patients at the New England Center for Headache decreased their migraine and cluster headache intensity by applying capsaicin cream to their nasal passages.
NSAID medications have potential side effects, even though many of these medications can be obtained over-the-counter. Some of the side effects are minor, other certainly worrisome. Some people may be more prone to side effects given other medical conditions. For that reason, NSAID medication should be used with caution. If there is ever a question of whether or not it is safe for you to take these medications, and you should discuss this with your doctor. Anyone taking NSAID medications for more than a few days should have a discussion with her physician about the potential for side effects.
Today, the most common conventional treatments for lower back pain relief are medications, including NSAIDS like aspirin and Tylenol, along with more potent prescription painkillers, such analgesics. These drugs can potentially cause adverse side effects in some patients and commonly don’t solve the underlying causes of lower back pain (such as poor posture, obesity or exercise-related strains). Some medications for back pains have even been tied to complications, such as liver damage or intestinal bleeding, when taken for long periods of time or in high doses.
Curcumin has also been suggested as a treatment for colitis, chronic neurodegenerative diseases, arthritis, and cancer. In addition, it regulates the activity of several enzymes and cytokines by inhibiting both COX-1 and COX-2. Most studies to date have been performed in animals, but given the centuries of use of curcumin, as well as its now demonstrated activity in the NF-kB, COX-1, and COX-2 inflammatory pathways, it may be considered a viable natural alternative to nonsteroidal agents for the treatment of inflammation.

If these aches and pains sound all too familiar, then there’s a whole host of safe and effective treatments available to get back pain relief and to then relieve arthritis pain – herbal remedies, special foods, over-the-counter medicines, exercises, and more (see our Arthritis Solutions Special Report for details). But the quickest and safest way to soothe arthritis pain is with a topical cream that contains:

Burdock root is a natural botanical for that is in wide use for many conditions, among them arthritic pain, swollen joints and rheumatism. More than anything else, clinical studies have found it most effective as a blood purifier that helps to rid the body of deleterious toxins and clear congestion from the circulatory, lymphatic, respiratory and urinary systems. Burdock is said to cleanse and eliminate long-term impurities from the blood very rapidly through its action on both the liver and kidneys. For those who suffer from arthritis and have taken too much Tylenol, burdock root has been clinical proven to protect the liver cells from the damage of taking acetaminophen. It is believed to stimulate the gallbladder and encourage liver cells to regenerate.
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