Diclofenac topical gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining of the joints) in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain.
In summer 2018 I had my first personal experience with dramatic relief from Voltaren Gel (topical diclofenac). It’s not the first time I have found it useful, but it was the first time it was amazing. I’d been having some unexplained knee pain intermittently for several weeks when it kicked up a notch or two and became constant and even started waking me up at night. When I finally remembered to try Voltaren Gel — I’m not sure what took me so long — things were bad enough that it was going to be obvious if it worked. And it was! After many days of constant discomfort ranging from 3-6 on a 10-scale, it just ended: half an hour after applying the stuff, I simply didn’t have that problem anymore. Hallelujah! It’s been weeks since then with no relapse. Although the pain was not terrible, this is actually one of the clearest examples of pain relief from any treatment that I’ve ever enjoyed.
Boswellia serrata is a traditional Indian Ayurvedic remedy for inflammatory conditions. It is extracted from the gum of the Indian boswellia tree and has been in use for centuries to treat joint pain and inflammation. It provides anti-inflammatory activity in areas where there is chronic inflammation by turning off the pro-inflammatory cytokines that begin the inflammatory process. Moreover, research shows that the acids contained within boswellia extract stop the formation of immune cells known as leukotrienes, which are responsible for inflammation. This then allows blood to flow unobstructed to the joints for healing and improved mobility.
That said, why not try it? It’s almost certainly safer than popping ibuprofen! Although not tested and approved for reckless experimentation on any pain problem, obviously the entire point of Voltaren® Gel is to limit exposure to the active ingredient. So you might choose to experiment — taking full responsibility for your actions, of course, and not suing me if something goes horribly wrong, because of course I’m not actually recommending it. 😉 Seriously: just run it by your doctor.
LoveHemp CBD Body Salve  is an infusion of cannabidiol within a lovely base of organic coconut oil, beeswax and argan oil. It is scented with organic rosehip and geranium oil and has a soft, waxy texture at room temperature. A 50 ml pot contains 300mg cannabinoids and you only need to apply a small amount to relieve muscle aches, joint pain and skin irritation.
Prostaglandins act as short-lived localized hormones that can be released by any cell of the body during tissue, chemical, or traumatic injury, and can induce fever, inflammation, and pain, once they are present in the intercellular space. Thromboxanes, which are also hormone activators, can regulate blood vessel tone, platelet aggregation, and clot formation to increase the inflammatory response.[92,82] The inflammatory pathway is a complex biochemical pathway which, once stimulated by injury, leads to the production of these and other inflammatory mediators whose initial effect is pain and tissue destruction, followed by healing and recovery.[34,51] A major component of the inflammatory pathway is called the arachidonic acid pathway because arachidonic acid is immediately released from traumatized cellular membranes. Membrane-based arachidonic acid is transformed into prostaglandins and thromboxanes partly through the enzymatic action of cyclooxygenase (COX)[34,57]. There are two types of COX enzymes, COX-1 and COX-2. Both the enzymes act similarly, but selective inhibition (as accomplished by selective COX-2 inhibiting NSAIDs) can make a difference in terms of side effects.

In a 2011 research review published in the British Journal of Anaesthesia, investigators looked at the available research on the use of topically applied capsaicin in the treatment of several types of chronic pain. This included two clinical trials examining back pain, both of which found that capsaicin helped reduce low back pain without causing notable side effects.
When sudden changes occur in the weather or we overexert ourselves during physical activity, those of us who experience, or who already had, muscle and/or joint pain treat ourselves with the traditional prescriptions of conventional anti-inflammatories. There is a general tendency for us to take anti-inflammatories every time something hurts, as if they were water. Nevertheless, the damage caused to our bodies (liver, stomach, etc.) by anti-inflammatories is highly significant if these are abused. Symptomatic use of analgesics, such as paracetamol, and non-steroidal anti-inflammatory drugs (NSAIDs) is almost always the first treatment option, and ibuprofen is one of the most widely used anti-rheumatic drugs.
Cruciferous vegetables like broccoli, cauliflower, and cabbage have several health benefits. They naturally support detox organs like the liver and kidneys, and they contain plenty of natural fiber, folate, and vitamin C. But they can also help to regulate inflammatory bacteria within the digestive tract, especially H. pylori, which is implicated in ulcers and other chronic digestive conditions. (25) Since the body obtains all of its nutrients via digestion, an inflamed digestive system will contribute to inflammation throughout the rest of the body. Eating cruciferous vegetables daily can help to promote the healthy elimination of toxins as well as the proper regulation of the digestive system.

For those amenable joints, though, Voltaren® Gel delivers a good dose of medication directly to the joint, while sparing the gastrointestinal tract from the harshness of NSAIDs — which are actually known as “gut burners,” and many people just can’t stomach ibuprofen. A gel almost completely eliminates the risks associated with digesting the stuff.4
Traditional wisdom says that NSAID pain relievers only damage your gut lining if you take them every day for a long time, but recent research disagrees. High-level athletes with stress-related intestinal damage tried taking ibuprofen to improve muscle soreness and recovery. Ibuprofen ended up damaging their gut lining even further after just a couple weeks; it increased inflammation and made their original pain issues worse.[3] In fact, a single dose of aspirin can significantly increase your intestinal permeability.[4]