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A 2015 Cochrane review of 61 studies involving nearly 8,400 people found that topical NSAIDs relieved pain from strains, sprains, and overuse injuries, but with less side effects than oral NSAIDs. Similarly, a 2006 review of four randomized trials found that topical diclofenac reduced knee pain due to osteoarthritis and was generally well tolerated. 
Boswellia serrata is a traditional Indian Ayurvedic remedy for inflammatory conditions. It is extracted from the gum of the Indian boswellia tree and has been in use for centuries to treat joint pain and inflammation. It provides anti-inflammatory activity in areas where there is chronic inflammation by turning off the pro-inflammatory cytokines that begin the inflammatory process. Moreover, research shows that the acids contained within boswellia extract stop the formation of immune cells known as leukotrienes, which are responsible for inflammation. This then allows blood to flow unobstructed to the joints for healing and improved mobility.
Cayenne pepper is also a potent candida killer. Scientists found it’s active against 16 different fungal strains, including candida, a common internal infection linked to joint pain, among other candida symptoms. (1) Cayenne also provides external pain relieve. Capsaicin, an important natural painkiller found in cayenne, helps treat muscle soreness, tension and even skin infections. Look for it in natural painkilling creams.
in December 1998, celecoxib (Celebrex) was approved by the Food and Drug Administration (FDA) as the first selective COX-2 inhibitor for treatment of arthritis pain.[92,13,22] Rofecoxib (Vioxx) was approved several months later, followed by valdecoxib (Bextra).[92,28,67,79] These NSAIDs were designed to allow continued production of the gastrointestinally protective prostaglandins produced through the COX-1 enzyme system while blocking the COX-2 enzyme that produces the inflammatory prostaglandins.[34,45,51,89]
Limited bed rest. Once the mainstay of treatment for back pain, bed rest has fallen out of favor. Doctors now know it's better to keep moving, so that your muscles don't become stiff. Bed rest can still be useful relief from low back pain, particularly if your pain is so severe that it hurts to sit or stand. But try to limit it to a few hours at a time and for no more than one or two days.
Hi Peggy, It’s not a treatment with which I am familiar. Looking at the incredients, Blue Ice contains alcohol which will cool by evaporating, an aspirin-like substance (methyl salicylate), magnesium (muscle relaxant) and capsicum which has a pain killing action by depleting nerve endings of nerve chemicals. It looks like it is effective for muscle and joint pain and has good reviews but I can’t speak from personal experience. Hope that helps, Sarah B
I purchased this because it was less expensive than Penetrex and I'd thought I'd try it out.. Unfortunately, compared to Penetrex, at least for me, I do not feel that it is worth the savings. I'm using it for Plantar Fasciitis and Osteoarthritis in my knees. Although it does provide some pain relief, the duration is limited to a couple hours, whereas Penetrex lasts for up to half a day. However, SynthaFlex does offer a little more relief, albeit very temporarily, for my Osteoarthritis than Penetrex does. It is not nearly as effective for my Plantar Fasciitis pain. Ultimately, if I have to apply it many times throughout the day, it is not cost effective in comparison.
The packaging for this Outback cream doesn’t look like that of your typical arthritis cream, and thousands of customers say it doesn’t work like one either. They say, in fact, that Outback works better than them. It was developed by Dave Ireland, aka the Wildlife Man, who couldn’t find relief from his arthritis pain, so he developed this and put his picture on it.
Many patients have told me they find celadrin cream effective for rapid relief of painful joints. It appears to work best when you apply it all around the joint – for example in a continuous band around the front, sides and back of a knee. One patient, who had two arthritic knees, told me he performed a personal experiment in which he applied celadrin cream around one knee but not the other. He was amazed at the difference in the treated knee which, within hours, became less painful and more mobile. Needless to say, he soon started applying it to both knees!
Apply to the affected area and massage into the skin gently. Always wash your hands after you have finished rubbing the cream, gel or spray into the skin. This is to make sure that you avoid rubbing this medicine into sensitive areas of the body such as the eyes. Do not apply to skin that is broken, or near the eyes, nose, mouth, genital or bottom (anal) areas. Do not use plasters or bandages (dressings) on top of these medicines. Generally these medicines are applied to the skin 2-4 times a day. However, for specific advice for your medicine, see the leaflet that comes inside the packet.

Author Bio: Ginevra Liptan, MD, developed fibromyalgia while in medical school. She is a graduate of Tufts University School of Medicine and board-certified in internal medicine. Dr. Liptan is the founder and medical director of The Frida Center for Fibromyalgia and the author of The FibroManual: A Complete Fibromyalgia Treatment Guide For You...And Your Doctor and The Fibro Food Formula: A Real-Life Approach to Fibromyalgia Relief.
As part of your exercise routine, you may want to consider doing yoga regularly for lower back pain relief. One study of over 960 people with low back pain found that those who completed a 12-week yoga program experienced greater improvements in back function and reduced pain compared to controls who did not participate. (4) There’s even evidence that mindfulness meditation, often practiced in some form with yoga, can also help people deal with chronic back pain more effectively. (5)
Almost every person with fibromyalgia describes their muscles as tight and full of painful muscle knots called trigger points. After I was diagnosed with fibromyalgia during medical school, I tried many different styles of massage, but got no benefit until I found a specialized technique called myofascial release pioneered by John Barnes, PT. This form of massage therapy involves using very slow but sustained gentle pressure to separate tiny adhesions in the muscle tissue and fascia, and this lessens muscle tension and gently breaks up knots in the connective tissue (to learn more about the vital importance of fascia in fibromyalgia, read my previous blog post). Two European studies found that myofascial release therapy was effective for reducing fibromyalgia pain, and that it gave long-lasting pain relief even at one month and six months after the last session. To find a John Barnes-trained therapist skilled in this technique go to www.mfrtherapists.com.
These proinflammatory cytokines result in chemoattractant for neutrophils and help them to stick to the endothelial cells for migration. They also stimulate white cell phagocytosis and the production of inflammatory lipid prostaglandin E2 (PGE2). NSAIDs’ ability to interfere with the production of prostaglandin during the inflammatory cascade is the major mechanism cited for the anti-inflammatory success of these medications [Figure 1].[112]

Curcumin has also been suggested as a treatment for colitis, chronic neurodegenerative diseases, arthritis, and cancer. In addition, it regulates the activity of several enzymes and cytokines by inhibiting both COX-1 and COX-2. Most studies to date have been performed in animals, but given the centuries of use of curcumin, as well as its now demonstrated activity in the NF-kB, COX-1, and COX-2 inflammatory pathways, it may be considered a viable natural alternative to nonsteroidal agents for the treatment of inflammation.


With more than 23,000 reviews on Amazon, customers give Penetrex sky-high marks for effective pain relief. If it doesn’t work for you, it comes with a 100 percent, no-questions-asked, money-back guarantee. Formulated to fight inflammation, it contains a mix of ingredients including arnica, choline, glucosamine, Vitamin B6, and MSM. It’s not odor-free, but rather has a light scent that disappears quickly after you apply it. You can use it alone or in conjunction with heating pads, massagers, ice, and other therapies.
I have gone through a jar using it on my lower back. It doesn't have a bad order, not greasy and absorbs quickly! Though the relief isn't permanent it does work on my back. Just recently I developed a bunion on my right foot. I started applying the Sciatica Pain Relief Cream. Oh, it hurt so much to touch my foot but I applied twice a day. Amazingly it gradually got less red, the pain lessened and now all the symptoms are gone - in two weeks!
Aspirin is now believed to target both the NF-kB and COX pathways. These agents inhibit the NF-kB pathway in endothelial cells and block NF-kB activation to inhibit leukocyte recruitment.[114,115,116] NSAIDs have also been found to inhibit both the COX system and the NF-kB pathway. Immunosuppressant drugs also reduce nuclear expression of NF-kB.[39,70,75] Research now indicates that blocking the activation of NF-kB along with other inflammation mediators [Table 2] is the major mechanism for reducing inflammation by natural compounds.
The Penetrex® inflammation formulations have received rave reviews on Amazon.com® since 2009. With the Penetrex® Pain Relief Cream you will need fewer applications, and it actually heals and repairs your problem without masking the pain. You can get around expensive prescription medications using this product. You will have no side effects and it is not addictive. The cream will increase and enhance your range of motion and flexibility when you have no pain to deal with.
We looked at both gels and creams to create our top ten list. How did we evaluate consistency? We looked at whether the substances stained, went on greasy, or were otherwise messy to deal with. Did users like the feel of the gel or cream on their skin? Why or why not? We also looked at whether formulas were quick drying and whether they left a residue. When it came to ingredients, we wanted to select as many options as possible with natural ingredients that were easily recognizable.
I’m often asked which is the strongest ibuprofen gel. If you’re looking for the best muscle pain relief, however, I recommend diclofenac gel rather than ibuprofen gel. Research shows that diclofenac gel (Voltarol) is stronger and more effective than even a strong ibuprofen gel. If you still prefer to use an ibuprofen gel, however, you can find them on Boots.com.
Warning: The gel is for external use only. It is flammable therefore keep it away from heat or open flames. Check with your healthcare provider before using it if you have sensitive skin are pregnant or breastfeeding. Do not put it near your eyes or mucous membranes or apply to wounds, sores, scratched or imperfect skin. Do not use this product with other creams, sprays, liniments, or ointments. Never put a bandage over the area. Stop using if your skin becomes red, has a rash, or feels irritated. Never use with a heating pad on top of the area and always wash your hands after using. Contact your doctor if problems continue after use. Consult your pediatrician if your child is under 2-years-old. Keep out of the reach of children.
People with sensitive skin, infants, children, pregnant women, and seniors might be at a higher use using these products. People with kidney problems or kidney failure in the past shouldn’t try an Ibuprofen cream. If you take aspirin, prescribed blood thinners such as Coumadin (warfarin) or have bleeding of the gastrointestinal tract, consult your healthcare provider before using these topical pain products. Do not use salicylates that cause blood to be thinner.
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Capsaicin cream, also called capsicum cream, is available in drug stores, health food stores, and online. A typical dosage is 0.025% capsaicin cream applied four times a day. The most common side effect is a stinging or burning sensation in the area. If possible, wear disposable gloves (available at drugstores) before applying the cream. Be careful not to touch the eye area or open skin. A tube or jar of capsaicin cream typically costs between $8 and $25.
Needless to say I stopped it at once and now use a herbal cream which I find works better, uses less and has no side effects, but of course is not on prescription. Within a week the cystolic reading had dropped somewhat but not the diastolic which is concerning. I trust that over the next few weeks it will return to normal. If anyone says that diclofenac gel is none harmful they are lying! I have at the same time found herbal remedies for two other chemical meds, and the difference in how I feel is marked.
In addition to the other methods and strategies discussed throughout my book, I recommend taking natural remedies that reduce pain and inflammation, protect joint health and promote healing without side effects. Below I offer an overview of 20 different supplements formulas or ingredients often found within such formulations. Read each, keeping in mind your specific condition and how some may be more effective for you than others.
People who use nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as topical diclofenac (Pennsaid, Voltaren) may have a higher risk of having a heart attack or a stroke than people who do not use these medications. These events may happen without warning and may cause death. This risk may be higher for people who use NSAIDs for a long time. Do not use an NSAID such as topical diclofenac if you have recently had a heart attack, unless directed to do so by your doctor.Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of your body, or slurred speech.
The most often neglected method to control inflammation that I see in my patients is rest. Not only does this mean resting from athletics, but often this means allowing an injured body part to rest from normal activities which may prolong inflammation. We live busy lives that may not allow for rest, but ignoring the signs of inflammation may prolong the problem. Therefore, look for ways to rest your injured body part to allow the inflammation to subside and the recovery process to unfold.
Green tea has long been recognized to have cardiovascular and cancer preventative characteristics due to its antioxidant properties. Its use in the treatment of arthritic disease as an anti-inflammatory agent has been recognized more recently. The constituents of green tea are polyphenolic compounds called catechins, and epigallocatechin-3 galate is the most abundant catechin in green tea.

For natural headache relief, two essential oils team up for natural pain relief. Peppermint oil improves circulation and lavender reduces muscle tension — two ways to quickly stop a headache in its tracks. Try placing a few drops of peppermint or lavender oil into your hands and then rubbing the blend on your forehead, temples and back of neck. You can also dilute a few drops down by mixing the essential oils with almond, grapeseed or coconut oil.
Injections. If other measures don't relieve your pain, and if your pain radiates down your leg, your doctor may inject cortisone — an anti-inflammatory medication — or numbing medication into the space around your spinal cord (epidural space). A cortisone injection helps decrease inflammation around the nerve roots, but the pain relief usually lasts less than a few months.
Try massage therapy. Studies have shown that massage therapy not only helps with relaxation, but can also help diminish the body's perception of pain. A high quality therapeutic massage spurs blood flow, which in turn helps nourish and heal the soft tissues in throughout your body. Massage also releases endorphins, which are your body's natural analgesics. Massage therapy is defined as soft tissue—muscles, tendons, and ligaments—manipulation through hands-on massage by a qualified massage therapist. Like many complementary therapies, there is no substantial agreement in terms of how much massage therapy can help reduce pain, or which type of massage is best for which type of pain, so you may need to try more than one approach to find what works best for you.
Although most cases of back pain are “uncomplicated” and should be able to heal with the treatments mentioned above, sometimes in severe cases other interventions are necessary. Speak to your doctor if you experience lower back pain that does not get better in a few days or weeks. If back pain starts suddenly, look out for other symptoms that may point to a more serious condition, such as a fever, chills, dizziness, numbness or unexplained weight loss.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with topical diclofenac 1% and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.
Also referred to as "hypnosis," hypnotherapy is a mind-body technique that involves entering a trance-like state of deep relaxation and concentration. When undergoing hypnotherapy, patients are thought to be more open to suggestion. As such, hypnotherapy is often used to effect change in behaviors thought to contribute to health problems (including chronic pain).
“I cannot even tell you how AMAZING this stuff is. I never do reviews, but this product most certainly deserves one. I have dealt with MANY injuries, I was in a bad car wreck, and I have had more surgeries than I could count on both hands. My main area of pain is my upper back and neck. I have bulging disks, cervical stenosis, degenerative disk disease that causes horrible spasms, swelling, tension, and PAIN. I also have cancer and several other issues that put my pain level over the top every day. I have seen neurosurgeons, all of whom say they will eventually need to operate. I have done absolutely every possible treatment other than a spinal fusion, have had probably 10 injections, and they even went and tried to burn the nerve endings throughout my entire cervical spine, yet nothing worked. I can't even begin to tell you the medications the doctors have tried, each of which help some, but you get to a point where you don't want to constantly take medications forever. One day I was at my spine doctor's office and they had a bottle of Relief pain cream on the counter. While I was waiting there I asked the staff some questions about Relief and thought "yea, yea, but can I try it?" So, I put some on, and thought, "HOLY COW! What is this! Whatever this is, it's amazing!" Then and there I literally bought the rest of the supply they had on-hand because I couldn't believe how much it helped relieve my pains and aches. That night, I couldn't sleep because I was in so much pain, and none of my medications were helping. I felt like I was dying. So again, I put on some Relief cream and it helped soooo much. Since that day I never, ever, go anywhere without Relief! I will use this pain cream forever and continue to tell everyone I know about it because it truly works! I'm so glad I randomly tried this stuff at the doctor's office because I finally found something that gives true RELIEF!!” *
Meditate twice daily. Meditation comes in many varieties, some complex, others simple. One common approach is just to find a sound that is pleasing to you but has no particular meaning (like "som"), close your eyes, sit still and comfortably, and repeat the sound in your mind. When your thoughts wander, notice that they have wandered and return to your sound. If you feel your pain, notice the pain and return to your sound.
1. Capsaicin. Capsaicin creams and gels are made from chili peppers.  They cause a mild to moderate burning sensation thought to alter nerves' ability to interpret pain by lowering the presence of a neurotransmitter called Substance P. Brand names including Capzasin and Zostrix are marketed for arthritis, backache, and other joint and muscle pains.  These creams aren't generally associated with any adverse side effects though some patients may feel the heat more intensely than others.

Turmeric root contains just 2% to 5% curcumin, so when reaching for a supplement, be sure you’re buying curcumin, not powered turmeric root. Curcumin is not easily absorbed by the digestive tract, so choose high-potency curcuminoids and combine with oil, since curcumin is fat-soluble. Black pepper extract (piperine), though not Bulletproof, has also been shown to increase curcumin’s bioavailability by 2000%.[13] However, some newer, high-tech curcuminoid formulas have been shown to offer the same potency levels without the use of piperine.[14]
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