The NF-kB molecule is a transcription factor that controls the transcription of DNA for the perpetuation of the inflammatory immune response. It acts as a switch to turn inflammation on and off in the body. NF-kB has the ability to detect noxious stimuli, such as infectious agents, free radicals, and other cellular injuries, and then directs DNA to produce inflammatory cytokines. The NF-kB proteins are localized in the cytoplasm of the cell and are associated with a family of inhibitory proteins known as inhibitor of kB (IkB).[43,119] The TNF-α, and especially IL-1b, can also directly stimulate enzymes known as matrix metalloproteinases, which break down extracellular collagen matrix, a hallmark of inflammatory joint disease.[32,76,77] The IkB proteins are normally bound to NF-kB and block their nuclear localization signal. A variety of provoking stimuli can degrade the IkB and result in the nuclear translocation of NF-kB to be free to activate DNA synthesis of inflammatory cytokines [Figure 2].

Ginger is in the same family of anti-inflammatory spices as turmeric. While they share similar benefits, ginger is well known for its ability to relieve nausea associated with pregnancy and cancer treatments. It can also relieve pain in the same category as NSAIDs, making it another effective alternative to over-the-counter medications that have unpleasant side effects. (18)


I am a science writer, former massage therapist, and I was the assistant editor at ScienceBasedMedicine.org for several years. I have had my share of injuries and pain challenges as a runner and ultimate player. My wife and I live in downtown Vancouver, Canada. See my full bio and qualifications, or my blog, Writerly. You might run into me on Facebook or Twitter.
When you suffer from recurring back pain, the last thing you want to do is become dependent on medication. Dr. Pat’s Ultra Freeze gel is a simple, non-intrusive solution to muscle aches and soreness that gets to work straight away, helping you get on with your daily life without pain. Designed to combat discomfort associated with arthritis and sciatica as well as muscle pain, the cooling gel comes in a larger than average container, meaning you can depend on it being there when you need it.
Yes, most of these creams can either be used on a daily basis or long-term basis. Nevertheless, at any given point in time, always ensure that you consult with your doctor to find out how often it would be advisable to use such forms of medication. The best quality ones are the ones that would be FDA approved and natural. Therefore, you should use these types of medication for as long as the health practitioners advise.
In a 2011 research review published in the British Journal of Anaesthesia, investigators looked at the available research on the use of topically applied capsaicin in the treatment of several types of chronic pain. This included two clinical trials examining back pain, both of which found that capsaicin helped reduce low back pain without causing notable side effects.
The only side effect most of these products have is odor. Some of them were reviewed as being neutral to actually smelling good, while others were reported to have quite a strong smell you might not like. A lot of this has to do with the nature of the ingredients in pain relieving treatments. Mentholated ingredients give natural relief, but they do tend to have a strong odor that accompanies them.
"I love to make my own home remedy to soothe sore muscles by adding 1-2 cups of Minera Dead Sea Salt ($42; sfsalt.com) and 5-8 drops of lavender essential oils to my bath. This combination draws out toxins, calms the parasympathetic system and helps aching muscles, while easing swelling and improving blood circulation. Afterwards, I'll apply some coconut oil to soothe dry skin.' —Nikki Warren, co-founder Kaia FIT
One way to increase the effectiveness of Biofreeze is to add it to a massage! And what do professional massage therapists use in their practice regularly? Creams and oils to help their hands glide across the skin and focus on relieving pain. External pain relief creams can be used as a part of your at-home massage to not only enhance your comfort, but to soak in and relieve any residual pain.
Burdock root is a natural botanical for that is in wide use for many conditions, among them arthritic pain, swollen joints and rheumatism. More than anything else, clinical studies have found it most effective as a blood purifier that helps to rid the body of deleterious toxins and clear congestion from the circulatory, lymphatic, respiratory and urinary systems. Burdock is said to cleanse and eliminate long-term impurities from the blood very rapidly through its action on both the liver and kidneys. For those who suffer from arthritis and have taken too much Tylenol, burdock root has been clinical proven to protect the liver cells from the damage of taking acetaminophen. It is believed to stimulate the gallbladder and encourage liver cells to regenerate.
NSAIDs don’t just damage your gut lining. They affect your gut bacteria, too. A study of regular users found that different NSAIDs caused different changes in gut bacteria.[5] Ibuprofen and arthritis drug celecoxib (Celebrex), for example, increased pathogenic Enterobacteriaceae, a family of bacteria that includes E. coli, Salmonella, and a number of lesser-known bacteria that contribute to eye, skin, respiratory, and urinary tract infections.[6]
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