Omega 3 fatty acid supplements are one of the most powerful ways to reduce oxidative stress and inflammation which are the underlying markers we see on labs with individuals who are suffering with chronic pain.   Omega 3’s help provide better cell membrane receptor activity and suppress genetic transcription factors associated with inflammation and pain.

Topical glucosamine cream and gel can significantly reduce the pain of knee osteoarthritis within 4 weeks. One study involving a glucosamine cream found that 100% of those with arthritis of the shoulder gained benefit. Of those with arthritis of the ankle, wrist or elbow, glucosamine cream reduced pain in 75% of people, and it worked in 58% of those with knee osteoarthritis.
Research shows that applying celadrin cetylated fatty acid cream with menthol to knees can reduce arthritis pain and improve the range of movement. Applying celadrin cream also makes it easier to climb up and down stairs. Celadrin cream cetylated fatty acids is also effective as a muscle pain relief cream to treat pain associated with trigger points in the neck.
This was a very informative post. I hate taking pills so anything thing that can help with any pain that I’m experiencing that you can just add topical is the best in my opinion. It’s great that it’s also as good as oral pain killers. And also has fewer side effects which is also another great thing. I’ll have to tell my friend about this because she has bad knee pain, so this would help her out a lot.
On September 30, 2004, Merck Research Laboratories announced the global withdrawal of rofecoxib (Vioxx), its primary selective COX-2–inhibiting NSAID.[52,90,122] Analysis of the results of the Adenomatous Polyps Prevention on Vioxx study (known as the APPROVe study) showed that there was double the risk of serious thromboembolic events, including myocardial infarction, which became apparent after 18 months of Vioxx treatment.[26] Selective COX-2 NSAID’s thrombotic mechanism of action is based on COX-1’s unopposed action to continued platelet synthesis of thromboxane. Thromboxane is a thrombogenic and atherogenic eicosanoid. Prostacyclin prevents formation of platelet clotting. By inhibiting COX-2 that blocks production of prostacyclin (PGI2) there is unopposed thromboxane which will increase the clotting risk. Thus, inhibiting prostacyclin led to the increased risk of thrombotic cardiovascular and cerebrovascular events.[5,26,73,123]
I recommend a woman takes 1,500 milligrams starting on the first day of her period and continuing until ovulation. If your’e on certain antidepressants, you have a bleeding or a seizure disorder, you’re on phenothiazine drugs for schizophrenia, or you’re being treated for high blood pressure, you should talk to your doctor before starting evening primrose oil.

QUORA EXPERT - TOP WRITER 2018 Dr Sarah Brewer MSc (Nutr Med), MA (Cantab), MB, BChir, RNutr, MBANT, CNHC qualified from Cambridge University with degrees in Natural Sciences, Medicine and Surgery. After working in general practice, she gained a master's degree in nutritional medicine from the University of Surrey. Sarah is a registered Medical Doctor, a registered Nutritionist and a registered Nutritional Therapist. She is an award winning author of over 60 popular self-help books and a columnist for Prima magazine.
Medications are not the only solution to control inflammation and discomfort. As we become increasingly aware and sensitive the possible side-effects of any medication, more patients and doctors alike are interested in non-pharmacologic methods to control inflammation. There are many ways that people address inflammation. Some have better scientific support than others, but most all are safe to try.
When it comes to relieving the pain of achy joints, many people reach for a pain-relieving pill like aspirin or ibuprofen. There may be a better way. When the source of pain is close to the surface, applying a cream, gel, patch, or spray that contains a pain reliever right where it hurts can ease pain and help avoid some of the body-wide side effects of oral pain relievers.

Pain is a leading cause of insomnia—difficulty with falling asleep and/or staying asleep. Approximately two-thirds of people with chronic back pain suffer from some type of sleep disorder. Paradoxically, inadequate sleep can make your back pain worse. This vicious cycle makes it ineffective to treat just the pain. If you have sleep problems, you need to get the sleep problems addressed too.
Feverfew. Feverfew has been used for centuries to treat headaches, stomachaches, and toothaches. Nowadays it's also used for migraines and rheumatoid arthritis. More studies are required to confirm whether feverfew is actually effective, but the herb may be worth trying since it hasn't been associated with serious side effects. Mild side effects include canker sores and irritation of the tongue and lips. Pregnant women should avoid this remedy.
Meditation and mindfulness. Mindfulness meditation, which focuses on awareness of the present moment, can reduce the way we perceive pain. In one study, only four days of training led to a 40% reduction in pain rating and a 57% reduction in pain-unpleasantness.[14] This kind of meditation can help you to control back pain, fibromyalgia, and migraines. Read more about meditation and mindfulness for pain control here.
SAMe is one of the natural chemicals made within the body that science has been able to duplicate in a lab, and make into a supplement. Studies have shown SAMe supplementation to be comparable to the pain-relieving effects of Celebrex by the second month of taking the product, without the side effects. The SAMe chemical has a role in pain, depression, liver disease and has been shown effective when used for relieving the symptoms of osteoarthritis, fibromyalgia, bursitis, Alzheimer’s disease, multiple sclerosis (MS), migraine headache, depression and more, making it a great natural remedy for inflammation.

Capsicum annum is a small spreading shrub which was originally cultivated in the tropical regions of the Americas but is now grown throughout the world, including the US. The small red fruit commonly used to accentuate chili owes its stinging pungency to the chemical, capsaicin. This was isolated by chemists more than a century ago and constitutes approximately 12% of the chili pepper. This fruit has been used for various medicinal purposes by the native peoples of the American tropics for hundreds of years.
Relief goes beyond common sport and muscle creams to relieve your pain.  With the highest level mixture of menthol and methyl salicylate of sports creams and balms, Relief quickly starts working.  Just one application of our non-greasy, no mess applicator provides the temporary relief you have been looking for.  Simply rub the balm on directly from the container – no more messy hands.  We take time tested ingredients that work and deliver them in an easy to use applicator to alleviate your muscle and joint pain.  Pick up some Relief and don’t let pain stop you.
Meditate twice daily. Meditation comes in many varieties, some complex, others simple. One common approach is just to find a sound that is pleasing to you but has no particular meaning (like "som"), close your eyes, sit still and comfortably, and repeat the sound in your mind. When your thoughts wander, notice that they have wandered and return to your sound. If you feel your pain, notice the pain and return to your sound.

Lower back pain and vaginal discharge: What to know Lower back pain and vaginal discharge are common on their own. When they occur together, this can point to specific medical issues. In this article, learn about seven possible causes of both lower back pain and vaginal discharge. We also describe risk factors, diagnostic methods, and treatment options. Read now


One concern about the use of products like Voltaren is that several conditions are less inflammatory in nature than they feel like. Patients usually assume that the “burning” pain of repetitive strain injuries like tendinitis is caused by inflammation, but in fact classic inflammation is largely absent, especially after initial flare-ups have died down (but pain is still carrying on). While it is possible, even likely, that tendinitis is still inflamed in some sense, it’s doubtful that they are inflamed in a way that NSAIDs are actually good for. The biochemistry of cranky tendons is rather complex and largely unknown. There’s probably some overlap between the biology of acute, classic inflammation and the subtler biology of chronic tendinitis, but no one really knows. So the value of Voltaren for tendinitis is unclear.
It may be tempting to quit exercising when you're suffering from back pain, but it's essential to keep yourself moving. Pilates is one great option. In a 2014 European Journal of Physical Rehabilitation Medicine study, researchers found an improvement in pain, disability, and psychological health in chronic low-back pain patients who took five hourlong Pilates classes a week for six months. Meanwhile, people who remained inactive experienced further worsening of their pain. Similarly, a Medicine and Science in Sport and Exercise study revealed that taking either Pilates or a general exercise class twice a week for six weeks both improved pain and quality of life.
If you have an attack of lower-back pain that is severe, continuous and not improving, assessment and treatment by a health care professional who focuses on the back or other musculoskeletal problems may help. These practitioners may use both active and passive techniques to help you feel better. Examples of passive techniques that may be used to get you moving include:
This is a good option for anyone suffering from minor arthritis pain or sore muscles. It has no odor and is perfect for rubbing into the back to relieve backaches and pain. This product does not use any heating or cooling feature, so it is perfect for someone who wants a smell-free pain relief cream without a lot of added features. People have been using this cream for decades, and many continue to prefer it.
In contrast, the guidelines of the American Pain Society and American College of Rheumatology have in the past recommended topical methyl salicylate and topical capsaicin, but not topical NSAIDs. This reflects the fact that the American guidelines were written several years before the first topical NSAID was approved for use in the United States. Neither salicylates nor capsaicin have shown significant efficacy in the treatment of OA.
The Boswellia species are trees located in India, Ethiopia, Somalia, and the Arabian Peninsula, and they produce a gum resin called olibanum, better known in the western world as frankincense. This resin possesses anti-inflammatory, anti-arthritic, and analgesic properties. Boswellia can inhibit the leukotriene biosynthesis in neutrophilic granulocytes by inhibiting 5-LOX, thus affecting various inflammatory diseases that are perpetuated by leukotrienes.[95] Clinically, the substance is used in the treatment of degenerative and inflammatory joint disorders. It reduces the total white blood cell count in joint fluid, and it also inhibits leukocyte elastase, which is released in rheumatoid arthritis. In one recent study, a statistically significant improvement in arthritis of the knee was shown after 8 weeks of treatment with 333 mg B. serrata extract taken three times a day. The treatment improved function, but radiographically there was no change in the affected joints.[62]

I’ve just emphasized that Voltaren is mainly appropriate for shallow inflammation, but there is some evidence that Voltaren might be able to “reach deeper.” This is hardly the stuff of medical certainty yet, but researchers Huang et al found that Voltaren treated pain coming from deep inside the spine, right in the centre.6 They concluded that it could be a “convenient and safe clinical intervention” for a few types of back pain. An anti-inflammatory gel will likely fail with many kinds of back pain, but there’s also virtually no down-side to trying. See my low back pain tutorial for extremely detailed information about medications for back pain.
The benefits of heat therapy are twofold: it increases the flow of healing oxygen and nutrients to the damaged area, and it suppresses pain signals. Some find that wearing a heat wrap, such as those from ThermaCare, is best because it releases a low level heat for several hours and can be worn under clothes so you can remain mobile. You can also combine the benefits of aromatherapy and a heat by adding an essential oil to the hot pack; you can experiment by making your own microwaveable heating pad at home and adding different essential oils to see what works best for you.
Hi Paul, This is not a condition I’m very familiar with. I’ve done a bit of research for you and found that most people will regain up to 70-90% of their original strength and functional levels within two years. The same reference suggests that ‘Specific pain medications used to treat PTS include opiates and non-steroidal anti-inflammatory drugs (NSAIDs), which are usually used in combination. … After the acute phase, different medications such as gabapentin, carbamazepine, and amitryptiline may be used specifically to treat nerve pain.’ It’s possible that diclofenac gel will help the pain – this is the most effective topical NSAID available without prescription. Your doctor can prescribe other versions. Nerve pain is difficult to treat topically, although capsaicin cream (chilli extract) is prescribed to treat other forms of nerve pain eg related to shingles. Physio will help the nerves to recover – a medical herbalist may be able to suggest herbal creams that might promote nerve regrowth. Hope that helps.
They are not also greasy and you can use apply it whenever you like. You can use it even when you are on a business meeting or you are on a party and no one will smell it due to its odorless feature. After using the pain relief products you feel relaxed within minutes and you feel healthy to work again. So don’t feel hesitate to have the best muscle pain relief cream nowadays and save a spot in your office or purse.

I am allergic to anti-inflammatory pills since they affect my stomach. I don't like the bad side effects they give either. So I look to topical anti-inflammatory cream to help when I have back, hip and/or shoulders sprains and strains. I have tried endless products: Penetrex, Aspercreme, Australian dream, Celadrin and so on. Out of these, Muscle Care works best for pain management. However, I do have some skin reactions to it so I have to give it a rest. When that happens, I use Topricin which works quite well. However, to me, SynthaFlex works as well, if not better. On top of that, it gives a strong cool menthol effect which Topricin doesn't. So when I overwork some muscles, I like to use SynthaFlex and/or Topricin. When my skin reactions calm down, I go back to using Muscle Care from time to time. I also use a roller to stretch which also helps. I hope this review gives others a better sense of what might work for them.
The cream is affordable, effective, and gives wonderful results. You will want to use products that keep you that way. The hot cream is available in a large 8.8-ounce orange jar with either a silver metal or white plastic lid and the contents are always the same. It is 100% natural and 87% organic. It will firm up and tone your skin and remove that stubborn cellulite. Additionally, it warms up your aching and sore muscles for relief from that pain. Another benefit is that by firming up and reducing fat, you can be as trim as you want to be.
Author Bio: Ginevra Liptan, MD, developed fibromyalgia while in medical school. She is a graduate of Tufts University School of Medicine and board-certified in internal medicine. Dr. Liptan is the founder and medical director of The Frida Center for Fibromyalgia and the author of The FibroManual: A Complete Fibromyalgia Treatment Guide For You...And Your Doctor and The Fibro Food Formula: A Real-Life Approach to Fibromyalgia Relief.
Research suggests that topical medications may be just as effective as oral ones. Many of them worked significantly better than placebo. These medications can come in the form of gels, creams, patches, and more. One study also saw decrease in pain when people applied lavender essential oil or ointments prepared with cayenne peppers with acupressure.
While most people are only looking to relieve the immediate symptoms of the pain, this will only provide temporary relief.  Addressing the underlying mental/emotional, chemical and physical stressors that are causing the chronic inflammation and pain is the ultimate goal.  This process takes time and deep introspection along with trusted holistic health care providers.
Achy back? You're not alone: back problems send more Americans to the doctor annually than nearly any other medical problem, according to a 2013 Mayo Clinic study. Whether you're recovering from misjudging a heavy load (we've all been there), dealing with a lingering injury, or have a chronic problem, you don't necessarily need to resort to popping tons of pain relievers. Talk to your doc about these 15 expert-approved natural back pain remedies, and find out if they are safe and appropriate for you.
Zeng C, Wei J, Persson MS, et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Br J Sports Med. 2018 Feb. PubMed #29436380. “Topical NSAIDs were effective and safe for OA. Diclofenac patches may be the most effective topical NSAID for pain relief. No serious gastrointestinal and renal AEs were observed in trials or the general population.” BACK TO TEXT
Whether it was brought on by arthritis, a structural or nerve problem, bending the wrong way, or lifting something a little too heavy, low back pain is frustrating as all get-out. But if you're struggling, know this: You're definitely not alone. Most people experience back pain at some point in their lives, and it's one of the most common reasons people book doctor's appointments and call out of work. It's also one of the leading causes of disability worldwide.
If you’re someone who experiences muscle and joint pain from time to time (or on a regular basis), you’ve probably tried quite a few options for pain relief. And you’re probably already using external pain relievers—the kind you apply directly to your skin for fast relief from sore muscles and joints. But have you thought of adding an external pain relief cream to the mix?

SynthaFlex uses Celadrin®. Celadrin® is a patented matrix of cetylated fatty acid esters. It reduces inflammation to relieve joint pain and increase joint mobility. It also helps restore synovial fluid that cushions bones and joints to promote flexibility without pain. As a topical cream, it's design to be rapidly absorbed by the dermis to provide fast and continuous relief.

Most of the active research with resveratrol has been done in neuro and cardioprotection, but several studies are being reported on resveratrol’s use for arthritic joint pain. Elmali et al, reported in 2007 using animals that intra-articular injection of resveratrol protects cartilage and reduces the inflammatory reaction in simulated knee osteoarthritis. The anti-inflammatory properties of resveratrol have also been observed in experimental animal models with paw edema, which is attributed to suppression of inflammatory prostaglandin synthesis.[29] Resveratrol is also a potent and specific inhibitor of TNF-α- and IL-1b-induced NF-kB activation. Resveratrol shows the anti-inflammatory properties as it suppresses COX-2 by blocking NF-kB activation.

Wasabi is another spicy food with natural painkilling properties. Scientists are studying the isothiocyanates in wasabi as potential pain relievers. Researcher from University of California San Francisco made a recent discovery suggesting that isothiocyanates could block an inflammation receptor, making it a potentially important natural painkiller. (2)


The Biofreeze® pain relief gel is available in 16-, 32-, or 128-ounce bottles and is offered as the colorless or original green formula. The company has been making pain relief products for over 25 years. It is the #1 product that has been clinically used by professional healthcare hands-on providers, massage therapists, physical therapists, chiropractors, foot doctors (podiatrists), athletic coaches, instructors, and trainers. This is considered the best pain relief cream for muscle pain perfect for athletes. When professionals have over a hundred clients each week, the economical 128-ounce jug might be best for you for not running out. You always want it on hand for clients with sore aching body parts.
Cayenne pepper is also a potent candida killer. Scientists found it’s active against 16 different fungal strains, including candida, a common internal infection linked to joint pain, among other candida symptoms. (1) Cayenne also provides external pain relieve. Capsaicin, an important natural painkiller found in cayenne, helps treat muscle soreness, tension and even skin infections. Look for it in natural painkilling creams.
LoveHemp CBD Body Salve  is an infusion of cannabidiol within a lovely base of organic coconut oil, beeswax and argan oil. It is scented with organic rosehip and geranium oil and has a soft, waxy texture at room temperature. A 50 ml pot contains 300mg cannabinoids and you only need to apply a small amount to relieve muscle aches, joint pain and skin irritation.
Sleep disturbances are common among people with chronic back pain, and not getting enough quality sleep may actually worsen inflammation and pain. For a better night's sleep, invest in a good mattress and experiment with different sleeping positions. Adding an extra pillow under your body can help maintain the natural curve in your spine. If you’re a back sleeper, try putting the pillow under both knees; for stomach sleepers, try under your pelvis. If you sleep on your side, sleeping with a pillow between the knees may help.
Our writers spent 5 hours researching the most popular arthritis creams on the market. Before making their final recommendations, they considered 30 different creams overall, screened options from 20 different brands and manufacturers, read over 50 user reviews (both positive and negative), and tested 1 of the creams themselves. All of this research adds up to recommendations you can trust.
Cannabidiol, or CBD, is extracted from non-marijuana strains of industrial hemp plants. CBD oil is one of the most popular supplements for pain when taken orally, and CBD creams, salves and ointments are equally effective for pain relief when applied directly to painful muscles and joints. CBD is absorbed through the skin to interact with cannabinoid receptors (CB2) and suppress inflammation, relieve local pain and reduce itching, irritation and soreness. You can use a CBD salve or ointment at the same time as taking CBD oil capsules which reduce pain perception within the brain, aid relaxation and sleep as well as reducing discomfort and fatigue. Click here to find out more about oral cannabidiol CBD oil supplements for pain.
These creams can be quite effective for temporary pain relief on the muscle and joints. The creams would also come in handy when handling inflammations that may be brought forth by minor injuries, sunburn, skin rash and other severe conditions. Although doctors would prescribe most of these creams for their patients, more often than not individuals go for the OTC medications to deal with simple medical conditions. When making your purchase for this particular product it is important that you make a comparison between active ingredients and the inactive ingredients used in the formulation of the cream. At the end of the day, ensure that you choose a product that would not have dire side effects on your health. The cream you choose should help you deal with your particular problem in the best way possible and if possible you should make sure that you consult with your doctor before using any of these creams.

SAMe is one of the natural chemicals made within the body that science has been able to duplicate in a lab, and make into a supplement. Studies have shown SAMe supplementation to be comparable to the pain-relieving effects of Celebrex by the second month of taking the product, without the side effects. The SAMe chemical has a role in pain, depression, liver disease and has been shown effective when used for relieving the symptoms of osteoarthritis, fibromyalgia, bursitis, Alzheimer’s disease, multiple sclerosis (MS), migraine headache, depression and more, making it a great natural remedy for inflammation.


The Biofreeze® pain relief gel is available in 16-, 32-, or 128-ounce bottles and is offered as the colorless or original green formula. The company has been making pain relief products for over 25 years. It is the #1 product that has been clinically used by professional healthcare hands-on providers, massage therapists, physical therapists, chiropractors, foot doctors (podiatrists), athletic coaches, instructors, and trainers. This is considered the best pain relief cream for muscle pain perfect for athletes. When professionals have over a hundred clients each week, the economical 128-ounce jug might be best for you for not running out. You always want it on hand for clients with sore aching body parts.
SynthaFlex uses Celadrin®. Celadrin® is a patented matrix of cetylated fatty acid esters. It reduces inflammation to relieve joint pain and increase joint mobility. It also helps restore synovial fluid that cushions bones and joints to promote flexibility without pain. As a topical cream, it's design to be rapidly absorbed by the dermis to provide fast and continuous relief.
Achy back? You're not alone: back problems send more Americans to the doctor annually than nearly any other medical problem, according to a 2013 Mayo Clinic study. Whether you're recovering from misjudging a heavy load (we've all been there), dealing with a lingering injury, or have a chronic problem, you don't necessarily need to resort to popping tons of pain relievers. Talk to your doc about these 15 expert-approved natural back pain remedies, and find out if they are safe and appropriate for you.
NSAID medications have potential side effects, even though many of these medications can be obtained over-the-counter. Some of the side effects are minor, other certainly worrisome. Some people may be more prone to side effects given other medical conditions. For that reason, NSAID medication should be used with caution. If there is ever a question of whether or not it is safe for you to take these medications, and you should discuss this with your doctor. Anyone taking NSAID medications for more than a few days should have a discussion with her physician about the potential for side effects.
Capsicum annum is a small spreading shrub which was originally cultivated in the tropical regions of the Americas but is now grown throughout the world, including the US. The small red fruit commonly used to accentuate chili owes its stinging pungency to the chemical, capsaicin. This was isolated by chemists more than a century ago and constitutes approximately 12% of the chili pepper. This fruit has been used for various medicinal purposes by the native peoples of the American tropics for hundreds of years.
Ginger is in the same family of anti-inflammatory spices as turmeric. While they share similar benefits, ginger is well known for its ability to relieve nausea associated with pregnancy and cancer treatments. It can also relieve pain in the same category as NSAIDs, making it another effective alternative to over-the-counter medications that have unpleasant side effects. (18)
This cream acts as a natural pain reliever with every application on the body. With this particular cream, you are assured of getting relieved from the pain that you may experience on the joints and muscles, back pain, and arthritis pain. It would also assist you in effectively dealing with bruises by helping you deal with pain while reserving the gentle touch.
Staying in bed for any prolonged period can make you stiff and increase pain. When you don’t move and bend, you lose muscle strength and flexibility. With bed rest, you lose about 1 percent of your muscle strength each day. And you can lose 20 to 30 percent in a week. It becomes more difficult to return to any activity. As you become weaker and stiffer your recovery takes longer.
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People who used an ointment that contains this plant-based extract for 5 days reduced the intensity of lower back pain by 95%, according to a 2009 study conducted by Merck (which manufactures the ointment). In comparison, a placebo group had a 38% reduction in pain during that same time, according to the study in the British Journal of Sports Medicine. Look for comfrey root ointment in health food stores or online. Just don't use it for more than 10 days at a time—it can be toxic.
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Digging a metal tool into a painful spot, such as the bottom of your foot if you’re dealing with plantar fasciitis, sounds like some sort of medieval torture practice. The Graston technique is an instrument-aided manual therapy that serves as a noninvasive way to deal with soft tissue ailments like achilles tendonitis, carpal tunnel syndrome, fibromyalgia, shin splints, back and shoulder pain, and other ailments. It’s even been proven to help relieve pain associated with chronic conditions like trigger finger and post-surgery pain in a way that can reduce the amount of painkillers administered.
Pain, heat, redness, and swelling (dolor, calor, rubor, tumor) are the classic manifestations of the inflammatory process. Abnormalities of the joints of the spine, associated muscles, tendons, ligaments and bone structural abnormalities can all result in pain and need for neurosurgical consultations. Typically, patients will not require immediate surgical intervention, and therefore require treatments to reduce pain and enhance quality of life activities.[71]
Those who have tried using this Neosporin product say that cuts and scrapes heal within three days when this ointment is applied and that pain subsides quickly. To properly use the ointment, be sure to first clean the affected area with mild soap or saline water. Apply the Neosporin and then use a bandage to properly protect the area while it heals.
This product has a huge market universally. It is used by more than 2 million individuals because of how effective it is in relieving pain and minimizing inflammation. Penetrex has been amongst the most renowned pain relief drugs for quite some time over the years and it is still being used widely that is why acquiring one for yourself would serve your needs greatly.
These proinflammatory cytokines result in chemoattractant for neutrophils and help them to stick to the endothelial cells for migration. They also stimulate white cell phagocytosis and the production of inflammatory lipid prostaglandin E2 (PGE2). NSAIDs’ ability to interfere with the production of prostaglandin during the inflammatory cascade is the major mechanism cited for the anti-inflammatory success of these medications [Figure 1].[112]

in December 1998, celecoxib (Celebrex) was approved by the Food and Drug Administration (FDA) as the first selective COX-2 inhibitor for treatment of arthritis pain.[92,13,22] Rofecoxib (Vioxx) was approved several months later, followed by valdecoxib (Bextra).[92,28,67,79] These NSAIDs were designed to allow continued production of the gastrointestinally protective prostaglandins produced through the COX-1 enzyme system while blocking the COX-2 enzyme that produces the inflammatory prostaglandins.[34,45,51,89]


One reviewer describes the Penetrex cream as “magic in a jar,” saying that it helps her cope with back discomfort that doesn’t respond to other pain-treatment methods, whether massage or physical therapy. People say that the Penetrex cream has helped them while recovering from injury or surgery, but many also use it on a daily basis to alleviate arthritis pain as well as the normal but nagging aches that can spring up later in life.
8. Capsaicin (Capsicum) – Found in hot chile peppers, this natural remedy does wonders for pain. Capsaicin, the active pain-reducing ingredient, temporarily desensitizes nerve receptors called C-fibers which cause the pain response. Capsaicin also diminishes soreness for 3 to 5 weeks while the C-fibers regain sensation. A single 60-min application in patients with neuropathic pain produced effective pain relief for up to 12 weeks. Patients at the New England Center for Headache decreased their migraine and cluster headache intensity by applying capsaicin cream to their nasal passages.

"My go-to muscle soothing product is Topricin Pain Relief Cream ($17; topicrin.com) as it is a combination of 11 homeopathic ingredients proven to be safe for your skin. I typically apply it to my lower back (where I've had trauma) before I go running and again before bed. I'm a believer!" —Kira Stokes, creator of The Stoked Method (Try her 30-day plank challenge to score tighter abs, faster.)
Jackson, M., & Tummon Simmons, L. (2018, April 1). Challenging case in clinical practice: Improvement in chronic osteoarthritis pain with use of arnica oil massage, therapeutic ultrasound, and acupuncture — A case report [Abstract]. Alternative and Complementary Therapies, 24(2), 60–62. Retrieved from https://www.liebertpub.com/doi/abs/10.1089/act.2018.29152.mja?journalCode=act
NSAIDs don’t just damage your gut lining. They affect your gut bacteria, too. A study of regular users found that different NSAIDs caused different changes in gut bacteria.[5] Ibuprofen and arthritis drug celecoxib (Celebrex), for example, increased pathogenic Enterobacteriaceae, a family of bacteria that includes E. coli, Salmonella, and a number of lesser-known bacteria that contribute to eye, skin, respiratory, and urinary tract infections.[6]
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