I am a science writer, former massage therapist, and I was the assistant editor at ScienceBasedMedicine.org for several years. I have had my share of injuries and pain challenges as a runner and ultimate player. My wife and I live in downtown Vancouver, Canada. See my full bio and qualifications, or my blog, Writerly. You might run into me on Facebook or Twitter.
Schematic showing that when a cell membrane is injured the arachidonic acid pathway is activated to initiate the local inflammatory response through the production of prostaglandins, thromboxanes, and leukotrienes. Their activation requires the enzymes COX and LOX. The NSAIDs can block COX action and thereby prevent the formation of the COX-derived inflammatory mediators. 5-HPETE = 5-hydroperoxyeicosatetraenoic acid; LTC4 = leukotriene C4; PGE2 = prostaglandin E2; PGF2 = prostaglandin F2; PGI2 = prostacyclin; TXA2 = thromboxane.
NSAID medications have potential side effects, even though many of these medications can be obtained over-the-counter. Some of the side effects are minor, other certainly worrisome. Some people may be more prone to side effects given other medical conditions. For that reason, NSAID medication should be used with caution. If there is ever a question of whether or not it is safe for you to take these medications, and you should discuss this with your doctor. Anyone taking NSAID medications for more than a few days should have a discussion with her physician about the potential for side effects.
Synovial fluid is a thick, slippery substance with a consistency similar to egg white. It acts like an oil and fills small cavities within the joint cartilage, providing oxygen and nutrients when the joint is resting. Synovial fluid also pushes the bones apart so they don’t rub together to cause pain. Glucosamine also provides building blocks for making new cartilage, and repairing damaged areas. Glucosamine is also known to damp down inflammation and act as a biological signal to stimulate tissue repair.
The main advantage of topical NSAIDs is the reduced exposure of the rest of the body to the product, which reduces the side effect profile. Given the toxicity of NSAIDs is related in part to the dose, it follows that topical treatments should have a better toxicity profile. Consequently, the cardiovascular risks of topical diclofenac, even in those with a high baseline risk of disease, should be negligible with the topical forms.

Ongoing pain can wreak havoc on your life, affecting your cherished relationships, finances, and your ability to get stuff done at work and at home. It can also interrupt your sleep and affect your mood. Because many other problems commonly occur along with chronic lower back pain, anything you can do for yourself that is a natural anti-depressant will help.

These creams can be quite effective for temporary pain relief on the muscle and joints. The creams would also come in handy when handling inflammations that may be brought forth by minor injuries, sunburn, skin rash and other severe conditions. Although doctors would prescribe most of these creams for their patients, more often than not individuals go for the OTC medications to deal with simple medical conditions. When making your purchase for this particular product it is important that you make a comparison between active ingredients and the inactive ingredients used in the formulation of the cream. At the end of the day, ensure that you choose a product that would not have dire side effects on your health. The cream you choose should help you deal with your particular problem in the best way possible and if possible you should make sure that you consult with your doctor before using any of these creams.
The use of non-steroidal anti-inflammatory drug (NSAID) medication is still the mainstay of most classically taught clinicians for joint and spine related inflammatory pain, despite their commonly known side effects [Table 1]. NSAID mechanisms are primarily through interaction with proinflammatory cytokines interleukin (IL)-1a, IL-1b, IL-6 and tumor necrosis factor (TNF-α). Increased concentrations of TNF-α are believed to cause the cardinal signs of inflammation to occur.[44]
From tissue spasms to neurological aches and from shooting aches to twist, this best muscle rub cream of Living Well Nutraceuticals is lab-accredited to heal all patterns of pain. Its exquisiteness is essentially fortified by the presence of Cetyl Myristoleate or CMO that enacts in depth over swelled up muscles, tendons and joints and eradicates the very inflammation—the root cause of all pains. The best muscle rub cream also owns Methylsulfonylmethane or MSM, which again reaches into the body cells and opens those up to prevent the aches affecting physique. The ointment is moreover nurtured with cruxes of Belladonna and Rhus Tox and caters enduring soothe. It comes in a 3oz density tube.
Massage. Various forms of body work can provide temporary pain relief. You can try full-body Swedish massage for  stress relief and relaxation; deep-tissue massage, which uses pressure and slow strokes on deeper muscle tissue to release knots and relieve tension; or myofascial release, which uses long, stretching strokes to relieve tension around the connective tissue of the muscles.
We looked at both gels and creams to create our top ten list. How did we evaluate consistency? We looked at whether the substances stained, went on greasy, or were otherwise messy to deal with. Did users like the feel of the gel or cream on their skin? Why or why not? We also looked at whether formulas were quick drying and whether they left a residue. When it came to ingredients, we wanted to select as many options as possible with natural ingredients that were easily recognizable.

A study involving 172 people with osteoarthritis of the knee compared the use of a arnica gel with a prescribed, nonsteroidal anti-iflammatory gel (the NSAID piroxicam) with 1g of gel applied three times a day for 4 weeks. The results showed a pain reduction of 16.5 in the arnica gel group versus only 8.1 in the NSAID gel group and the researchers concluded that the Arnica gel was at least as effective and as well tolerated as the NSAID gel. A similar trial involving over 200 people with osteoarthritis of the hands showed that arnica gel was just as effective as an NSAID (ibuprofen) gel in reducing pain and improving hand function.


Meditation has been proven to reduce chronic pain in several scientific studies. Research from Duke University found that people suffering from chronic back pain saw significant reductions in pain and psychological distress after practicing a form of meditation that focuses on releasing anger. In another study, meditators experienced a 40% reduction in pain intensity.

Having a variety of solutions for pain relief is not only helpful, it’s strategic. Depending on which type of pain you’re experiencing, you want a personalized option. And having different solutions on hand helps you be prepared for whatever life throws at you. Try adding an external pain relief cream to the mix so you can relieve muscle and joint pain, then get back to doing what you love.
NSAIDs have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects. Although different NSAIDs have different structures, they all work by blocking cyclooxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation. Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

Low and lower back pain can vary from dull pain that develops gradually to sudden, sharp or persistent pain felt below the waist. Unfortunately, almost everyone, at some point during life will experience low back pain that may travel downward into the buttocks and sometimes into one or both lower extremities. The most common cause is muscle strain often related to heavy physical labor, lifting or forceful movement, bending or twisting into awkward positions, or standing in one position too long.
Topical anti-inflammatories work in the same way but, instead of having an effect on all of the body, they only work on the area to which you have applied them. When they are applied they are taken into (absorbed into) your skin. They then move deeper into areas of the body where there is inflammation (for example, your muscle). They relieve pain and reduce swelling affecting joints and muscles when rubbed into the skin over the affected area. Using a topical preparation means that the total amount of anti-inflammatory in your body is very low. This in turn means that you are much less likely to have a side-effect to this medicine.
I am allergic to anti-inflammatory pills since they affect my stomach. I don't like the bad side effects they give either. So I look to topical anti-inflammatory cream to help when I have back, hip and/or shoulders sprains and strains. I have tried endless products: Penetrex, Aspercreme, Australian dream, Celadrin and so on. Out of these, Muscle Care works best for pain management. However, I do have some skin reactions to it so I have to give it a rest. When that happens, I use Topricin which works quite well. However, to me, SynthaFlex works as well, if not better. On top of that, it gives a strong cool menthol effect which Topricin doesn't. So when I overwork some muscles, I like to use SynthaFlex and/or Topricin. When my skin reactions calm down, I go back to using Muscle Care from time to time. I also use a roller to stretch which also helps. I hope this review gives others a better sense of what might work for them.
Our writers spent 5 hours researching the most popular arthritis creams on the market. Before making their final recommendations, they considered 30 different creams overall, screened options from 20 different brands and manufacturers, read over 50 user reviews (both positive and negative), and tested 1 of the creams themselves. All of this research adds up to recommendations you can trust.
Ginger can be eaten raw or pickled, grated or brewed into tea, added as a spice to dishes, or encapsulated. Ginger tea or capsules seem to be the most efficient way to regularly consume it. You can drink up to four cups of tea daily, and capsules should follow daily recommendations or what practitioners suggest. Similar to turmeric, those on blood thinners should consult their doctors before adding daily ginger to their diet.
I am a science writer and a former Registered Massage Therapist with a decade of experience treating tough pain cases. I was the Assistant Editor of ScienceBasedMedicine.org for several years. I’ve written hundreds of articles and several books, and I’m known for readable but heavily referenced analysis, with a touch of sass. I am a runner and ultimate player. • more about me • more about PainScience.com

MSM is a potent sulfur naturally found in plants, animals and humans that helps rebuild the connective tissue in your joints and is a powerful natural remedy for inflammation and pain. What’s more, MSM has the unique ability to improve cell permeability. This allows harmful toxins to flow out, while allowing health boosting nutrients to flow in to feed your joints, cartilage and connective tissue. It is used for hundreds of symptoms related to a myriad of health diseases and conditions, and is especially effective as a natural remedy for relieving inflammation for improved joint function, and pain associated with joint inflammation, osteoarthritis, rheumatoid arthritis, osteoporosis and tendonitis. One study published in the Journal of AntiAging Medicine found that MSM provides an 80 percent greater reduction in pain compared to the placebo.
5. Birch Leaf (Betula Lenta) – The leaves from the Birch tree act much like cortisone, a prescription drug used to treat endocrine disorders, arthritis, lupus, skin disease, autoimmune disorders, and more. A main chemical compound found in Birch leaves is methyl salicylate, similar to salicylic acid used in aspirin. It is anti-spasmodic, analgesic, astringent, antifungal, diuretic, detoxifying, reduces oxidative damage to skin (stopping wrinkles), and enhances circulation. It also promotes enzymatic secretions in the body. It is truly one of the first powerful pain-relievers ever used.
Cognitive behavioral therapy can benefit your health and well being in numerous ways. It is a therapeutic technique that helps you to identify negative thoughts, emotions, and behaviors and learn how to replace them with productive alternatives. Cognitive behavioral therapy is an effective treatment for chronic pain,[15,16] as you learn to respond less to your pain and live a life less controlled by your pain.
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