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The most commonly used drugs to treat chronic pain conditions include opioids (morphine), nonsteroids (salicylates such as aspirin and ibuprofen), antidepressants, antiepileptics and anti-nerve growth factor inhibitors.   All of these drugs have awful side effects and addictive tendencies.  In fact, prescription and over the counter pain medications are the fastest growing drug addiction in North America (1).
QUORA EXPERT - TOP WRITER 2018 Dr Sarah Brewer MSc (Nutr Med), MA (Cantab), MB, BChir, RNutr, MBANT, CNHC qualified from Cambridge University with degrees in Natural Sciences, Medicine and Surgery. After working in general practice, she gained a master's degree in nutritional medicine from the University of Surrey. Sarah is a registered Medical Doctor, a registered Nutritionist and a registered Nutritional Therapist. She is an award winning author of over 60 popular self-help books and a columnist for Prima magazine.
If you suffer from arthritis or other types of pain, you're probably all too familiar with drugs such as aspirin, Aleve, and Naproxen. All belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and all can be purchased without a prescription. But there is another related drug, available by prescription, you might want to talk with your doctor about: diclofenac, available as a gel, patch, or drop that you apply directly to your skin.
Topical glucosamine cream and gel can significantly reduce the pain of knee osteoarthritis within 4 weeks. One study involving a glucosamine cream found that 100% of those with arthritis of the shoulder gained benefit. Of those with arthritis of the ankle, wrist or elbow, glucosamine cream reduced pain in 75% of people, and it worked in 58% of those with knee osteoarthritis.
Over the past two decades, evidence has emerged to demonstrate that topical versions of NSAIDs are well absorbed through the skin and reach therapeutic levels in synovial fluid, muscle, and fascia. … For chronic conditions like osteoarthritis, the data are of fair quality and are persuasive. On balance, there’s good evidence to show that topical NSAIDs are clinically- and cost-effective for short term (< 4 weeks) use, especially when pain is localized.
Gentle stretches, walking, and periodically standing up at your desk can help stabilize your spine and prevent muscle imbalances. And despite how hard it is to imagine doing Downward-Facing Dog with a bad back, yoga can work in your favor, too. A 2013 review of studies found strong evidence it can help beat lower back pain. Any type works; one to consider is the restorative viniyoga style.
A combination of Boswellia and curcumin showed superior efficacy and tolerability compared with nonsteroidal diclofenac for treating active osteoarthritis. Boswellia typically is given as an extract standardized to contain 30-40% boswellic acids (300-500 mg two or three times/day). Boswellia has been well tolerated in most studies, although some people may experience stomach discomfort, including nausea, acid reflux, or diarrhea.[1–10,42,48,56,62,103,104]

Warning: The gel is for external use only. It is flammable therefore keep it away from heat or open flames. Check with your healthcare provider before using it if you have sensitive skin are pregnant or breastfeeding. Do not put it near your eyes or mucous membranes or apply to wounds, sores, scratched or imperfect skin. Do not use this product with other creams, sprays, liniments, or ointments. Never put a bandage over the area. Stop using if your skin becomes red, has a rash, or feels irritated. Never use with a heating pad on top of the area and always wash your hands after using. Contact your doctor if problems continue after use. Consult your pediatrician if your child is under 2-years-old. Keep out of the reach of children.
The NSAIDs are also known to have adverse effects on kidney function.[31] Dehydration or preexisting chronic renal failure or disease, resulting in stimulation of the renin–angiotensin system, may predispose certain populations to acute renal failure through inhibition of prostaglandin synthesis, which can occur when taking NSAIDs.[31] The National Kidney Foundation asserts that approximately 10% of kidney failures per year are directly correlated to substantial overuse of NSAIDs.
One of the products I like mixes bromelain, curcumin, and quercetin. This powerful trio provides enhanced support for maintaining a healthy inflammatory response to reduce pain. Another favorite is a blend that contains essential nutrients the body needs to repair and recover, along with potent herbal pain alleviators, including black cohosh, white willow bark, valerian, and devil’s claw. Lastly, I suggest a high-potency proteolytic enzyme product combined with rutin. This supports the body’s natural processes for tissue and joint recovery. The enzymes work synergistically with rutin to naturally boost muscle and tissue repair.
Chondroitin sulphate chains bind to hyaluronic acid to form ‘springy’ molecules that increase the strength and elasticity of cartilage, making it more resilient. Chondroitin also acts as a signal to inhibit the enzymes responsible for breaking down cartilage, and to increase the production of collagen. Chondroitin is therefore an ideal complement to glucosamine and the two are often combined in joint and muscle pain relief creams.
Acetylsalicylic acid works by irreversibly disabling the COX enzymes to block the cascade [Figure 1]. NSAIDs have evolved from blocking both COX-1 and COX-2 to selectively only blocking COX-2 in order to inhibit the inflammatory response and reduce the production of inflammatory prostaglandins and thromboxanes. The major push to develop the selective COX-2 inhibitors has been the recognition of significant complications associated with the nonselective COX-1 and COX-2 NSAIDs. Nonselective NSAIDs’ major side effects include significant gastrointestinal upset, gastritis, ulceration, hemorrhage, and even death. By locking COX-1, which also normally acts to protect the gastrointestinal mucosa, nonselective NSAIDs and aspirin can cause significant gastric tissue damage.[34,51,78,91,3,101,115]

1., 2., and 3. Ginger, Turmeric, & Holy Basil – This set of herbs forms a sort of trinity in Ayurvedic medicine. All of them have anti-inflammatory properties. Turmeric (a curry ingredient) contains curcumins which ease inflammatory conditions like rheumatoid arthritis and psoriasis, according to the Methodist Research Institute in Indianapolis. “Each herb has its own scientific database of evidence,” says James Dillard, MD, author of The Chronic Pain Solution.
They are not also greasy and you can use apply it whenever you like. You can use it even when you are on a business meeting or you are on a party and no one will smell it due to its odorless feature. After using the pain relief products you feel relaxed within minutes and you feel healthy to work again. So don’t feel hesitate to have the best muscle pain relief cream nowadays and save a spot in your office or purse.
For natural headache relief, two essential oils team up for natural pain relief. Peppermint oil improves circulation and lavender reduces muscle tension — two ways to quickly stop a headache in its tracks. Try placing a few drops of peppermint or lavender oil into your hands and then rubbing the blend on your forehead, temples and back of neck. You can also dilute a few drops down by mixing the essential oils with almond, grapeseed or coconut oil.
10. Cherries – Due to the presence of compounds called anthocyanins—the same phytonutrients that give cherries their rich ruby hue – you can count on cherries to tamp down pain. Muraleedharan Nair, PhD, says, “They block inflammation and they inhibit pain enzymes, just like aspirin, naproxen, and other nonsteroidal anti-inflammatories.” Cherries are said to have the highest anti-inflammatory content of any food, making them great for remedying issues such as arthritis.

For centuries, natural anti-inflammatory compounds have been used to mediate the inflammatory process and often with fewer side effects. We have briefly reviewed several of the most commonly used plant- and animal-derived natural compounds that may possess similar effectiveness in treating the inflammatory reaction seen in both chronic and sub-acute pain syndromes encountered in a typical neurosurgical practice. Ongoing experiments and clinical trials should be continued to guide and provide their scientifically based effectiveness to reduce inflammation and promote wellness.

A study involving 172 people with osteoarthritis of the knee compared the use of a arnica gel with a prescribed, nonsteroidal anti-iflammatory gel (the NSAID piroxicam) with 1g of gel applied three times a day for 4 weeks. The results showed a pain reduction of 16.5 in the arnica gel group versus only 8.1 in the NSAID gel group and the researchers concluded that the Arnica gel was at least as effective and as well tolerated as the NSAID gel. A similar trial involving over 200 people with osteoarthritis of the hands showed that arnica gel was just as effective as an NSAID (ibuprofen) gel in reducing pain and improving hand function.
Whether the pain that someone experiences is activity related, leftover from an old injury, or due to a chronic inflammatory condition, bone broth in the diet can help to reduce chronic pain and flares. This is due to the presence of collagen in bone broth, which can help to alleviate joint problems and repair pain that originates from the digestive tract. (23)
Bromelian is a mix of proteolytic enzymes (those found in pineapples), which have been used for centuries to help indigestion and reduce inflammation. Studies indicate this product helps reduce pain associated with arthritis, especially when used in combination with some other natural pain-relieving agents making it a great natural remedy for inflammation and pain.
No, the lower back pain isn't in your head. But what is in your head could be making it worse. "Fear, anxiety, and catastrophizing can amplify pain," says Mackey. "People often get swept up in thoughts like This will never get better." Because brain circuits that process pain overlap dramatically with circuits involved with emotions, panic can translate into actual pain. Cognitive-behavioral therapy helps you recognize and reframe negative thoughts. Deep breathing can help, too, as can simply shining a light on dark thoughts. "Start by accepting that you have pain," Mackey says. "Then say to yourself, It will get better."
Celebrex, Vioxx, and Bextra quickly became the mainstay for the treatment of chronic pain conditions related to inflammation.[71] Within a few years, an estimated 15–20 million people in the US were using selective COX-2–inhibiting NSAIDs on a long-term basis. These drugs became the most commonly used pharmaceutical agent with more than 70 million NSAID prescriptions written each year and 30 billion over-the-counter NSAID tablets sold annually. It was estimated that 5–10% of the adult population used NSAIDs, and among the elderly (a group at higher risk of nonselective NSAID-induced gastrointestinal complications), the use of these drugs was as high as 15%. The general acceptance of these drugs was due to the perceived lack of serious gastrointestinal side effects that had been associated with the nonselective class of NSAIDs.[26,119]

Prostaglandins act as short-lived localized hormones that can be released by any cell of the body during tissue, chemical, or traumatic injury, and can induce fever, inflammation, and pain, once they are present in the intercellular space. Thromboxanes, which are also hormone activators, can regulate blood vessel tone, platelet aggregation, and clot formation to increase the inflammatory response.[92,82] The inflammatory pathway is a complex biochemical pathway which, once stimulated by injury, leads to the production of these and other inflammatory mediators whose initial effect is pain and tissue destruction, followed by healing and recovery.[34,51] A major component of the inflammatory pathway is called the arachidonic acid pathway because arachidonic acid is immediately released from traumatized cellular membranes. Membrane-based arachidonic acid is transformed into prostaglandins and thromboxanes partly through the enzymatic action of cyclooxygenase (COX)[34,57]. There are two types of COX enzymes, COX-1 and COX-2. Both the enzymes act similarly, but selective inhibition (as accomplished by selective COX-2 inhibiting NSAIDs) can make a difference in terms of side effects.

If you’re sensitive to aspirin, or if you’re taking any over-the-counter (OTC) anti-inflammatory drugs (like aspirin, ibuprofen, or naproxen), you should avoid willow bark. You should also avoid taking it if you’re taking warfarin (Coumadin) or other anticoagulant treatments, as salicin could increase the risk of bleeding. Talk to your doctor before taking willow bark if you’re taking other anti-inflammatory or pain medications.