This herb has been shown to prevent the activation of the transcriptional factor NF-kB and it directly inhibits TNF-α production by up to 65-85%. It inhibits the expression of inducible genes associated with inflammation, specifically negating the expression of inducible nitric oxide synthase, and hence attenuates nitrous oxide production. Side effects may include nausea, although it has shown an impressive protective effect on indomethacin-induced enteritis in laboratory studies.
Jackson, M., & Tummon Simmons, L. (2018, April 1). Challenging case in clinical practice: Improvement in chronic osteoarthritis pain with use of arnica oil massage, therapeutic ultrasound, and acupuncture — A case report [Abstract]. Alternative and Complementary Therapies, 24(2), 60–62. Retrieved from https://www.liebertpub.com/doi/abs/10.1089/act.2018.29152.mja?journalCode=act
The only side effect most of these products have is odor. Some of them were reviewed as being neutral to actually smelling good, while others were reported to have quite a strong smell you might not like. A lot of this has to do with the nature of the ingredients in pain relieving treatments. Mentholated ingredients give natural relief, but they do tend to have a strong odor that accompanies them.
While adding turmeric as a spice to foods tastes good, it has to be eaten in pretty large quantities to get a medicinal effect, as our gut does not absorb it well. The maximum pain relief effects are usually found with supplements that contain curcumin optimized for absorption (such as curcumin phosphatidylcholine complex). I like Meriva by Thorne Research, typical dosage of 500-1000mg twice daily. Although curcumin is much safer than anti-inflammatory medications, it does have some mild blood-thinning effects, so make sure to ask your health care provider before starting supplementation.
When used together, menthol and methly salicylate create vasodilation (opening of the blood vessels) close to the surface of the skin.  Increased blood flow to the area of application is said to have pain-killing on the nerve receptors in the treated area.  When combined, these two ingredients also work together to form a class of treatment called counterirritants. Counterirritants work by tricking the body into feeling sensations other than pain. The menthol and methyl salicylate in muscle creams create conflicting feelings of warmth and cold. When the nervous system sends both of these sensations, at the same time, they compete with and ultimately block pain signals from travelling to the brain.  Together these ingredients, when delivered in muscle creams or sports balms, work to create a powerful 1-2 punch, killing pain and providing relief to aching muscles and joints.
If you are the type of consumer who yearns for a natural muscle relaxer cream to help you solve the problem of experiencing sore muscles at different points in time more so after a tedious exercising activity then this is the type of cream to buy. With the cream, you would be able to deal with inflammation, chronic pain and sports injuries without much of a hustle.
While these are not the only risks NSAID medications, they are somewhat more common, and some of the more worrisome, side effects. It is always safest to have a discussion with your physician if you have any concerns about the risk of taking these medications. It is important to understand that even in healthy people without underlying medical conditions, there is always the risk associated with any medication. The benefits of taking an anti-inflammatory medication need to be balanced with the possible risks of taking the medication.
Homeopathic (diluted) herbal ointments featuring Arnica are claimed to be good medicine for muscle pain, joint pain, sports injuries and bruises, but their effectiveness is questionable. Known to most customers as an “herbal” arnica cream, most actually contain only trace amounts — too little to be a chemically active ingredient. Homeopathy involves extreme dilution of ingredients, to the point of completely removing them. Some other herbal ingredients may be less diluted and more useful. However, neither homeopathic or pure herbal creams of this type have produced results better than placebo in good quality modern tests. See Does Arnica Gel Work for Pain? A detailed review of popular homeopathic (diluted) herbal creams and gels like Traumeel, used for muscle pain, joint pain, sports injuries, bruising, and post-surgical inflammation. BACK TO TEXT
I have just read here that diclofenac gel is one of the best anti- inflam gels. What it does not say is that if you need to use it on more than one area of the body as I do, and only once a day before bedtime, that after the relatively short time of 6-8 weeks it can raise the B/P significantly in people like me for instance who have never had hypertension!
“I was first introduced to Relief by my Chiropractor after I pulled a muscle. Later my son, while playing hockey, received a very nasty hit during a game and was given Biofreeze as part of his recovery process. I can tell you Relief is 10x better—he was still in pain after using the Biofreeze, so I grabbed the Relief and he could not believe the difference. Now we are a Relief ONLY household. I am spreading the word to all the other hockey mom’s on the quality of your product and how well it works. Thank you for creating Relief and keep up the good work.” *
To avoid unwanted weight gain, consuming inflammatory ingredients or complications due to nutrient deficiencies, reduce or eliminate the following foods: added sugar, sweetened beverages or snacks, refined vegetable oils, refined grain products, too much alcohol and tobacco products (smoking impairs blood flow and adds to nutrient deprivation to spinal tissues).
Curcumin is a naturally occurring yellow pigment derived from turmeric (Curcuma longa), a flowering plant of the ginger family. It has traditionally been used as a coloring and flavoring spice in food products. Curcumin has long been used in both Ayurvedic and Chinese medicines as an anti-inflammatory agent, a treatment for digestive disorders, and to enhance wound healing. Several clinical trials have demonstrated curcumin’s antioxidant, anti-inflammatory, and antineoplastic effects. Results of a study by Zandi and Karin suggested that curcumin might be efficacious in the treatment of cystic fibrosis because of its anti-inflammatory effect.[121] Curcumin is known to inhibit inflammation by suppressing NF-kB, restricting various activators of NF-kB as well as stemming its expression.
Rolfing not only relieves physical muscle pain rooted in your fascia, but also improves your emotional well-being and energy. Whether you’re an athlete looking to improve your game or someone suffering with TMJ pain, chronic back pain or spine pain, rolfing is something worth exploring. It’s a potent natural painkiller that impacts your neuromuscular system in a positive, pill-free way.
If you find yourself snacking at night before bed, it may be because you're bored or anxious — not truly hungry — and eating makes you feel better. Try eating a healthy dinner a bit later in the evening. If your stomach is truly growling before bed, try a protein-based snack like a hard-boiled egg or a slice of cheese. A few spoonfuls of yogurt or some fruit is another good option. 

Water, Menthol, MSM, Glycerin, Dipropylene Glycol, Celadrin, Camphor, Cetearyl Alcohol / Cetearyl Glucoside, Beeswax, Microcrystaline Wax, Butylglycerin, Kyounin Yu, Macadamia, Integrifolia Seed Oil, Glyceryl Stearate / PEG-100 Stearate, Dimethicone, Hyaluronic Acid, Portulaca Oleracea Extract, Allantoin, Licorice Root Extract, Arginine, Carbomer, Lavender Oil, Peppermint Oil, Disodium EDTA, Polyacrylate-13/Polyisobutene / Plysorbate 20
The original Aspirin, white willow bark contains salicin which, in the stomach, converts to salicylic acid—the primary component of Aspirin. Synthetically, it can irritate the stomach, but naturally through white willow bark, it is effective in relieving pain, inflammation and fever. The recommended dose is 1 to 2 dropperfuls of white willow bark tincture daily.
Bark from the white willow tree is one of the oldest herbal remedies for pain and inflammation, dating back to ancient Egyptian, Roman, Greek, and Indian civilizations, as an analgesic and antipyretic agent. Because of the gastric side effects of aspirin, there has been a resurgence in the use of white willow bark for the treatment of inflammatory syndromes. The mechanism of action of white willow bark is similar to that of aspirin which is a nonselective inhibitor of COX-1 and COX-2, used to block inflammatory prostaglandins.[48]
Customers say that while they were skeptical at first, they are pleasantly surprised by just how well this lotion from Two Old Goats works to relieve arthritis pain. Its name come from its key ingredient—goat’s milk—which is blended with essential oils, including lavender, rosemary, peppermint, and eucalyptus in a formula designed to penetrate deep into your joints and muscles. All those oils also act as a moisturizer so it keeps your skin looking great too, and the pump bottle makes it easy to dispense.
Acetylsalicylic acid works by irreversibly disabling the COX enzymes to block the cascade [Figure 1]. NSAIDs have evolved from blocking both COX-1 and COX-2 to selectively only blocking COX-2 in order to inhibit the inflammatory response and reduce the production of inflammatory prostaglandins and thromboxanes. The major push to develop the selective COX-2 inhibitors has been the recognition of significant complications associated with the nonselective COX-1 and COX-2 NSAIDs. Nonselective NSAIDs’ major side effects include significant gastrointestinal upset, gastritis, ulceration, hemorrhage, and even death. By locking COX-1, which also normally acts to protect the gastrointestinal mucosa, nonselective NSAIDs and aspirin can cause significant gastric tissue damage.[34,51,78,91,3,101,115]

A muscle pain relief cream will alleviate aches and pains associated with sore muscles, injuries, inflammation, and more! The best muscle pain relief cream is the one that suits your unique needs. Some offer heating or cooling sensations, while others are odorless or made with natural oils to produce pleasant scents. A pain relief cream can also reduce arthritis discomfort! With plenty of creams to choose from, we've rounded up the top creams. You're sure to find the one that meets your needs in this list.


you should know that you should not apply sunscreens, cosmetics, lotions, moisturizers, insect repellents, or other topical medications to areas treated with diclofenac gel (Voltaren). If you have been prescribed diclofenac liquid (Pennsaid), wait until the area of application is completely dry before applying any of these products or other substances.

Comfrey root has a long history of traditional use to heal wounds and fractures when applied as a poultice, and was commonly known as ‘knit bone’. Modern research shows that comfrey contains two main active ingredients: allantoin which promotes tissue regeneration, and rosmarinic acid which damps down inflammation and reduces pain. Comfrey root cream is a popular and effective treatment for joint pain, sprains and strains.
Boswellia serrata is a traditional Indian Ayurvedic remedy for inflammatory conditions. It is extracted from the gum of the Indian boswellia tree and has been in use for centuries to treat joint pain and inflammation. It provides anti-inflammatory activity in areas where there is chronic inflammation by turning off the pro-inflammatory cytokines that begin the inflammatory process. Moreover, research shows that the acids contained within boswellia extract stop the formation of immune cells known as leukotrienes, which are responsible for inflammation. This then allows blood to flow unobstructed to the joints for healing and improved mobility.
In addition to the other methods and strategies discussed throughout my book, I recommend taking natural remedies that reduce pain and inflammation, protect joint health and promote healing without side effects. Below I offer an overview of 20 different supplements formulas or ingredients often found within such formulations. Read each, keeping in mind your specific condition and how some may be more effective for you than others.
You are eligible for a full refund if no ShippingPass-eligible orders have been placed. You cannot receive a refund if you have placed a ShippingPass-eligible order. In this case, the Customer Care team will remove your account from auto-renewal to ensure you are not charged for an additional year and you can continue to use the subscription until the end of your subscription term.
For a blast of cool pain relief, Biofreeze has been a go-to for arthritis sufferers for decades. Made with 4 percent menthol, this gel promises immediate relief from pain that’s long-lasting. It has a light green color, so you can see where you’re applying it, but it also comes in a colorless version as well. Both versions are greaseless and have a scent that’s designed to disappear after application.
Some manufacturers inflate nutraceutical products’ claims and may not cite possible side effects and potential drug interactions. Bleeding complications are associated with white willow bark, ginger, garlic, and others. Therefore, such medicinal preparations are not without risk. Products such as omega-3 essential fatty acids (EFAs) (O3) do have strong scientific support to be considered as an alternative and/or complementary agent to NSAIDs. Published studies have shown the effectiveness of O3 to successfully treat spine-related pain.[71] Capsaicin, oil of camphor, and other natural topical preparations are commonly used for muscle soreness and local application for painful traumatic injuries.[12,16,80] The subsequent sections will review many of these products and discuss both their efficacy and safety issues. As with any drug or natural compounds, additional caution should be used when considering these treatments for children, pregnant or lactating mothers or any other clinical or disease condition that could increase possible risk of side effect or complication.
Back pain can interrupt your day or interfere with your plans. In fact, there’s an 84 percent chance that you will develop low back pain in your lifetime. But back pain isn’t always something you can ignore or wait for it to resolve on its own. Thankfully, there are several ways to treat back pain at home. These remedies include everything from herbs to massages. Keep reading to see how you can ease your back pain.

Ensure that the type of anti-inflammatory cream you buy for yourself, a friend, or family member is of the right quality and more efficient in helping you deal with your health predicaments. The best quality brands would be fast acting and gentle to your skin with every application. Most of all, the cream that you choose at any given point in time should not have any side effects otherwise you would be exposing yourself to the ordeal of tackling what would result from using the poor quality creams in hopes of dealing with a minor injury. The best cream would take the shortest period to help relieve you of any kind of pain or inflammation so that you would comfortably carry on with whatever you might be doing.

If you’ve got a taste for hot stuff, you likely know some level of pain is involved. Interestingly, though, hot foods like wasabi and cayenne pepper can actually act as natural painkillers. Cayenne pepper benefits include several types of natural pain relief. The powerful pepper actually helps alleviate post-operative pain, including pain relief after a mastectomy or amputation.
Nearly everyone suffers from some type of back pain at some point in their lives. But no matter when it appears or what may have caused it, back pain can be a real, well … pain to deal with. The good news? There are several simple things you can do to ease pain and keep your back in good condition. The following tips can help you get on the way toward feeling better.

Authors of a 2016 review published in Seminars in Arthritis & Rheumatism conclude, “Topical NSAIDs have a moderate effect on pain relief, with efficacy similar to that of oral NSAIDs, with the advantage of a better risk:benefit ratio.” However, A 2016 Cochrane review looked at 39 studies with 10,631 participants and found that topical diclofenac, “can provide good levels of pain relief in osteoarthritis, but only for about 10% more people than get this result with topical placebo.”
"I have used your Arthritis Pain Relief Cream for a couple of years now, and I don’t know how I could do without it. I have arthritis in my back, arms, legs, and fingers. When I’m hurting, I apply the Cream, and the pain is gone in just a few minutes. I have referred this product to several friends and relatives. I also like your Intensive Night Repair Cream. I can’t live without it."

Its active ingredients include eucalyptus oil and tea tree oil, but nothing that will heat up your skin or provide the icy, cooling sensation that some other arthritis creams do. It comes in a roller-ball format, which you use to massage the product into the skin. Devoted fans say it’s the best pain-relief cream on the market, and they love that it doesn’t come with a lingering medicinal scent.

Many of the 10 million Americans suffering from widespread muscle pain due to fibromyalgia look for non-prescriptions options for pain relief. As a physician with fibromyalgia myself, I want to share with you the most effective natural options that I include in my own pain relief “toolbox,” which includes anti-inflammatory herbs, topical creams, and a unique form of massage that breaks up painful muscle knots.


I have just read here that diclofenac gel is one of the best anti- inflam gels. What it does not say is that if you need to use it on more than one area of the body as I do, and only once a day before bedtime, that after the relatively short time of 6-8 weeks it can raise the B/P significantly in people like me for instance who have never had hypertension!
How it works: A misaligned spine can cause muscle tension (read: pain). Both physical therapy and chiropractic treatment improve spinal alignment. Physical therapists strategically stretch and strengthen the muscles that help hold the spine in place. Chiropractors manipulate the spine to relieve areas of tension on the muscles. Consult your primary-care doctor for a referral.
Turmeric root contains just 2% to 5% curcumin, so when reaching for a supplement, be sure you’re buying curcumin, not powered turmeric root. Curcumin is not easily absorbed by the digestive tract, so choose high-potency curcuminoids and combine with oil, since curcumin is fat-soluble. Black pepper extract (piperine), though not Bulletproof, has also been shown to increase curcumin’s bioavailability by 2000%.[13] However, some newer, high-tech curcuminoid formulas have been shown to offer the same potency levels without the use of piperine.[14]
×