You are older than 65. “A lot of elderly patients can’t take oral NSAIDs because they have stomach or heart risk factors, and they can’t take narcotic analgesics because they could become so drowsy they could fall and break a bone,” says Roy D. Altman, MD, professor of medicine in the division of rheumatology and immunology at the University of California, Los Angeles.

One of the problems with pain relief creams is that application can become messy. It can be difficult to keep the cream contained to the area of skin that needs treating, and if you get the product on your hands, it’s easy to accidentally rub it into the eyes, which can be painful! To the rescue: Roll-on formulas, like Outback All-Natural Pain Relief, which allow for hands-free and targeted pain relief. The product contains just four ingredients: tea tree oil, vanilla, eucalyptus, and olive oil. The ingredients ease pain by reducing inflammation.
Hi Pauline, sorry to hear about your knee. Yes, capsaicin/capsicum cause stimulation of nerves endings so their chemicals are depleted and they reduce the level of pain messages they send on. The brain also naturally dismisses persistent signals. Some people do find it irritating, however, but better than the traditional treatments that mimic this action -bee stings and nettles! Best wishes, Sarah B
Schematic showing another inflammatory pathway that is activated by tissue injury. This is the NF-kB activation, in which once the protein is free as a result of tissue injury, it can enter the cell nucleus and activate the DNA to enhance the inflammatory response further by the production of additional cytokines, chemokines, and adhesion molecules (IKKB = IkB kinase)
Direct from the Kalahari Desert comes devil’s claw, a claw-shaped fruit that has been used for centuries by the South African tribes as a natural remedy for inflammation and to treat arthritis pain. Numerous studies carried out on devil’s claw show it to have powerful natural NSAID-like properties. In fact, the journal Phytomedicine reported that it is just as effective as the osteoarthritis medication Diacerein. What’s more, studies carried out in both France and Germany pointed to devil claw’s effects being similar to cortisone.
We looked at both gels and creams to create our top ten list. How did we evaluate consistency? We looked at whether the substances stained, went on greasy, or were otherwise messy to deal with. Did users like the feel of the gel or cream on their skin? Why or why not? We also looked at whether formulas were quick drying and whether they left a residue. When it came to ingredients, we wanted to select as many options as possible with natural ingredients that were easily recognizable.

Injections. If other measures don't relieve your pain, and if your pain radiates down your leg, your doctor may inject cortisone — an anti-inflammatory medication — or numbing medication into the space around your spinal cord (epidural space). A cortisone injection helps decrease inflammation around the nerve roots, but the pain relief usually lasts less than a few months.
Many patients have told me they find celadrin cream effective for rapid relief of painful joints. It appears to work best when you apply it all around the joint – for example in a continuous band around the front, sides and back of a knee. One patient, who had two arthritic knees, told me he performed a personal experiment in which he applied celadrin cream around one knee but not the other. He was amazed at the difference in the treated knee which, within hours, became less painful and more mobile. Needless to say, he soon started applying it to both knees!
Perform vends this distinguished muscle rub cream, which carves its own niche amongst counterparts, principally for the impeccable effectiveness over persistent type muscle and tendon pains. The Non-NSAID graded salve is recommended for after training physiology refurbishing endeavor and is an indispensable elect for treating both minor and severe tissue lesion issue. It is crafted by availing the innate analgesic feature of Menthol and is judiciously sans Paraben. The muscle rub cream is also operative over arthritis and muscle redness and comes in a 4oz volume gel tube. It scales to an extent 1.5 x 2 x 6.2 inches and is vended in two more patterns of Roll-On and Spray.
Many pharmaceutical pain medications, while effective and useful at times, can be downright dangerous, but there is another solution to your pain problem. “Almost always, if we find pharmaceuticals doing the trick, we’ll find a plant doing the same trick—and doing it more safely,” remarks botanist James A. Duke, PhD, author of The Green Pharmacy Guide to Healing Foods.

7. White Willow Bark (Salix alba) –  The active ingredient in white willow is salicin, which the body converts into salicylic acid. This tree’s covering lowers the body’s levels of prostaglandins, hormone-like compounds that can cause aches, pain, and inflammation. What’s more, white willow bark doesn’t upset the stomach or cause internal bleeding like many over-the-counter aspirins. Turn to this herb for relief from menstrual cramps, muscle pains, arthritis, or after knee or hip surgery as it promotes blood flow and reduces swelling.
It may be tempting to quit exercising when you're suffering from back pain, but it's essential to keep yourself moving. Pilates is one great option. In a 2014 European Journal of Physical Rehabilitation Medicine study, researchers found an improvement in pain, disability, and psychological health in chronic low-back pain patients who took five hourlong Pilates classes a week for six months. Meanwhile, people who remained inactive experienced further worsening of their pain. Similarly, a Medicine and Science in Sport and Exercise study revealed that taking either Pilates or a general exercise class twice a week for six weeks both improved pain and quality of life.
How old is your bed? You may be surprised to learn that the average life span of a mattress is less than 10 years. "There's no hard-and-fast rule," says Sean Mackey, chief of the division of pain medicine at Stanford University, "but if your mattress is sagging significantly or is more than 6 to 8 years old, I'd think about getting a new one. Something else to consider: a firm mattress may not do your back any favors, says Carmen R. Green, a physician at the University of Michigan Back & Pain Center. A number of studies over the years suggest that people with lower back pain who sleep on medium-firm mattresses do better than those with firm beds.
Low and lower back pain can vary from dull pain that develops gradually to sudden, sharp or persistent pain felt below the waist. Unfortunately, almost everyone, at some point during life will experience low back pain that may travel downward into the buttocks and sometimes into one or both lower extremities. The most common cause is muscle strain often related to heavy physical labor, lifting or forceful movement, bending or twisting into awkward positions, or standing in one position too long.
Over the past two decades, evidence has emerged to demonstrate that topical versions of NSAIDs are well absorbed through the skin and reach therapeutic levels in synovial fluid, muscle, and fascia. … For chronic conditions like osteoarthritis, the data are of fair quality and are persuasive. On balance, there’s good evidence to show that topical NSAIDs are clinically- and cost-effective for short term (< 4 weeks) use, especially when pain is localized.
One way to increase the effectiveness of Biofreeze is to add it to a massage! And what do professional massage therapists use in their practice regularly? Creams and oils to help their hands glide across the skin and focus on relieving pain. External pain relief creams can be used as a part of your at-home massage to not only enhance your comfort, but to soak in and relieve any residual pain.

ASU is a vegetable extract made from the oil of avocados and soybeans that is said to slow the progression of osteoarthritis. It slows down the production of inflammatory chemicals in the body and thus the breakdown of cartilage in the joints. It has also been found to spur new cartilage cell growth. It is available in capsule form at a recommended 300 mg daily.


Hi Patricia, Sorry to hear about your experience. The patient information leaflet for diclofenac gel inside each pack advises that users should avoid applying on large areas of skin, that an amount ranging in size from a 1 penny to a 2 pence piece will usually be sufficient, and not to use it if you are already taking NSAID tablets. High blood pressure is not listed as a possible side effect, as this was not detected in clinical trials. As you say, diclofenac tablets and other oral NSAIDs are now associated with an increased risk of cardiovascular disease which is why the gel is considered a better option. I have coverd this in a post about ibuprofen increasing blood pressure here. Research looking into the long-term tolerability of topical diclogenac gel in people with an elevated risk of NSAID-related side effects, such as existing high blood pressure, type 2 diabetes, stroke and heart disease, suggests that the gel appears to be safe to use to treat osteoarthritis, even in these high risk groups. Having said that, everyone is different, due to the genes they have inherited, and you may have experienced an unusual, idiosyncratic reaction to the small amounts absorbed via the skin. It’s good that you or your doctor were monitoring your blood pressure to detect this. I have a website dedicated to lowering a high blood pressure, which includes lots of complementary approaches, that you may find helpful. Are you able to share the name of the herbal cream which you have found works better? Best wishes, Sarah B
The benefits of heat therapy are twofold: it increases the flow of healing oxygen and nutrients to the damaged area, and it suppresses pain signals. Some find that wearing a heat wrap, such as those from ThermaCare, is best because it releases a low level heat for several hours and can be worn under clothes so you can remain mobile. You can also combine the benefits of aromatherapy and a heat by adding an essential oil to the hot pack; you can experiment by making your own microwaveable heating pad at home and adding different essential oils to see what works best for you.
7) The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. Li M, Bolduc AR, Hoda MN, Gamble DN, Dolisca SB, Bolduc AK, Hoang K, Ashley C, McCall D, Rojiani AM, Maria BL, Rixe O, MacDonald TJ, Heeger PS, Mellor AL, Munn DH, Johnson TS. J Immunother Cancer. 2014 Jul 7; PMID: 25054064
A combination of Boswellia and curcumin showed superior efficacy and tolerability compared with nonsteroidal diclofenac for treating active osteoarthritis. Boswellia typically is given as an extract standardized to contain 30-40% boswellic acids (300-500 mg two or three times/day). Boswellia has been well tolerated in most studies, although some people may experience stomach discomfort, including nausea, acid reflux, or diarrhea.[1–10,42,48,56,62,103,104]
Turmeric root contains just 2% to 5% curcumin, so when reaching for a supplement, be sure you’re buying curcumin, not powered turmeric root. Curcumin is not easily absorbed by the digestive tract, so choose high-potency curcuminoids and combine with oil, since curcumin is fat-soluble. Black pepper extract (piperine), though not Bulletproof, has also been shown to increase curcumin’s bioavailability by 2000%.[13] However, some newer, high-tech curcuminoid formulas have been shown to offer the same potency levels without the use of piperine.[14]
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